All articles tagged with #randomized trial
A citywide randomized trial in Singapore found releasing Wolbachia-infected male mosquitoes drastically reduced dengue transmission by about 71% and lowered local mosquito counts, providing robust evidence that IIT-SIT can control dengue.
A small UK Phase IIa randomized, placebo-controlled trial found that a single dose of DMT with psychotherapy significantly reduced depressive symptoms for up to three months (some participants up to six); 47% reached remission at three months. DMT appeared safe and well tolerated, but the study's small size means larger, longer trials are needed before it could become a standard depression treatment.
A large randomized trial of over 2,800 seniors found that a speed-based brain-training program, delivered in under 24 hours total, was associated with a 25% lower risk of developing dementia over 20 years based on Medicare records, while two other training types showed no significant effect; researchers call it a gold-standard study but note wide margins of error and several limitations that limit generalizability, signaling the need for further research.
Two parallel randomized trials found that a two-day oatmeal-only diet lowered LDL and total cholesterol by about 10% with effects lasting six weeks, while six weeks of replacing one daily meal with oats did not change cholesterol. The benefit is linked to rapid gut microbiome shifts and oat phenolics from a high-dose oat exposure, suggesting short, intensive oat interventions may aid cholesterol management but are not a substitute for an overall heart-healthy diet.
Endocrinologist Leigh Perreault led PATHWEIGH, a structured primary-care pathway that dedicates visits to weight management and streamlines workflows to reduce stigma and barriers. In a NIH-funded rollout across Colorado's 56 clinics, a large 18-month trial with 274,182 patients found that population weight gain fell by 0.58 kg and the overall trend shifted toward weight loss, with a 23% uptick in weight-related care and more anti-obesity prescriptions, prompting broader interest from health systems.
A small randomized controlled trial found that people lost twice as much weight when consuming minimally processed foods compared to ultraprocessed foods, despite similar nutritional content, highlighting the impact of food processing on weight and health.
A randomized trial conducted by the Rush Alzheimer's Disease Center found no significant improvement in cognitive function or changes in brain morphology after three years among older adults following the MIND diet compared to a control diet group with mild caloric restriction. The MIND diet, which combines elements of the Mediterranean and DASH diets, has been previously associated with preserving brain health. The study suggests that previous mixed results in diet trials may be due to research bias, confounding factors, or differences in study design and execution.