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Protein Analysis

All articles tagged with #protein analysis

health-and-medicine2 years ago

"Uncovering Five Variants of Alzheimer's Disease: A Potential Breakthrough in Treatment"

Researchers have identified five variants of Alzheimer's disease based on proteins found in the cerebrospinal fluid, potentially explaining the high failure rate of treatments. Each variant exhibits distinct molecular causes and genetic profiles, suggesting the need for tailored treatments. The study's findings could lead to the development of targeted drugs for each subtype, offering promising new strategies for treating the disease.

via IFLScience|
#alzheimers-disease#health-and-medicine#neurodegenerative-condition
health2 years ago

"Breakthrough: Five Distinct Types of Alzheimer's Uncovered, Potential for Cure"

Dutch scientists have identified five subtypes of Alzheimer's disease by analyzing proteins in the cerebrospinal fluid of over 400 patients, each with different clinical progression and life expectancy. These findings could explain why some drugs have been ineffective and may lead to more targeted and effective treatments. The study also revealed specific genetic links to each subtype and highlighted the need for personalized treatments for Alzheimer's patients. With rates of dementia expected to rise, the burden on health systems is increasing, making these findings crucial for future care and treatment.

via Daily Mail|
#alzheimers-disease#dementia#health
science-and-technology2 years ago

Streamlining Structural Biology: Innovations in Soft-Landing Techniques

Soft-landing mass spectrometry, a technique that gently lands intact proteins for analysis, shows promise in simplifying protein structure determination for cryo-electron microscopy (cryo-EM). By minimizing damage to proteins during the landing process, researchers have achieved near-atomic-resolution cryo-EM structures for proteins. This method could revolutionize protein sample preparation, allowing for the generation of high-resolution protein structures with greater precision and efficiency. However, further research is needed to optimize the technique and ensure that proteins retain their natural structure throughout the process. Soft-landing mass spectrometry also holds potential for single-molecule protein analysis and other structural analysis methods.

via Nature.com|
#cryo-electron-microscopy#mass-spectrometry#protein-analysis
science2 years ago

Oldest Genetic Study Identifies Ancient 'Outsider' Human Species

Researchers have used protein analysis of fossilized teeth to predict genetic relationships between early hominins, providing valuable insights into the evolutionary family tree of human beings. The study focused on teeth from an ancient relative called Paranthropus robustus, found in South Africa's Swartkrans cave. By comparing the results with DNA information from other fossils and modern hominids, the researchers tentatively placed P. robustus as an "outgroup" to the evolutionary line that includes Homo sapiens, Neanderthals, and Denisovans. The study demonstrates the feasibility of recovering informative early hominin enamel proteins and could be applied to other geologically-comparable sites in Africa.

via ScienceAlert|
#fossil-teeth#genetic-study#hominins