Tag

Proteasome

All articles tagged with #proteasome

science14 days ago•5 min saved

Brain Cells with a Built-In Defense Against Dementia Found

A CRISPR-based screen in human neurons with disease-causing tau mutations identified the CRL5SOCS4 protein complex as a key driver of tau protein degradation, helping some brain cells resist toxic tau clumps and dementia. Findings align with brain atlas data showing higher CRL5SOCS4 expression correlates with cell survival, and researchers note mitochondrial dysfunction can increase pathogenic tau fragments. Potential therapies include boosting CRL5SOCS4 activity or protecting proteasomes to enhance tau clearance.

via ScienceAlert|

#alzheimers-disease #crispr #mitochondria

science17 days ago•7 min saved

Aging Reveals a Brain Protein Switch—and Diet May Reset It

Aging destabilizes the brain’s protein ubiquitylation system, with reduced proteasome activity causing damaged proteins to accumulate and shift in activity, potentially driving cognitive decline and vulnerability to neurodegenerative disease. Notably, a short calorie-restriction diet in old mice significantly altered ubiquitylation patterns, in some cases reversing them toward a youthful state, suggesting diet can influence brain aging and that ubiquitylation could serve as a biomarker for age-related neural decline.

via SciTechDaily|

#aging #brain #diet

science2 months ago•6 min saved

Israeli Scientist Named Among Nature's Top Ten Science Shapers

Israeli scientist Prof. Yifat Merbl was named one of the top 10 shapers of science in 2025 by Nature for her groundbreaking research on cellular proteasomes and discovery of antimicrobial peptides, which could lead to advances in cancer immunotherapy, antimicrobial drugs, and disease diagnostics, despite facing setbacks like lab destruction during war.

via The Jerusalem Post|

#antimicrobial-peptides #immunology #nature-top-ten-list

neuroscience2 years ago•3 min saved

Proteasome's New Role in Brain Synapses Unveiled.

The 19S regulatory particle, a component of the cellular proteasome machinery, has been found to have an independent role in regulating synaptic proteins at the synapses in the brain, according to a study published in Science. Using super-resolution imaging technique DNA PAINT, researchers discovered an abundance of free 19S particles interacting with synaptic proteins, suggesting a novel regulatory mechanism. This discovery may provide new targets for understanding and treating neurological diseases with dysfunctional synapses like dementia and Parkinson’s disease.

via Neuroscience News|

#dna-paint #neurological-disorders #neuroscience

health2 years ago•3 min saved

The Surprising Benefits of Cold for Aging and Health.

Cold temperatures activate a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging. The proteasome activator PA28γ/PSME3 mitigated the deficits caused by aging in both the nematode and in the human cells. Aging is a major risk factor for several neurodegenerative diseases associated with protein aggregation, including Alzheimer's, Parkinson's, Huntington's and ALS. The research was conducted at the University of Cologne's CECAD Cluster of Excellence in Aging Research.

via Medical Xpress|

#aging #cold-temperature #health

health3 years ago•5 min saved

Stem Cells' Trash Removal Key to Fighting Aging.

Researchers at the University of California San Diego School of Medicine found that blood stem cells use an unexpected method to remove misfolded proteins, and that this pathway’s activity degrades with age. The study focused on hematopoietic stem cells (HSCs), the cells in our bone marrow that produce new blood and immune cells throughout our lives. The authors say boosting this specialized garbage disposal system called aggrephagy could help protect against age-related diseases.

via Neuroscience News|

#aggrephagy #aging #health