All articles tagged with #proteasome
Israeli scientist Prof. Yifat Merbl was named one of the top 10 shapers of science in 2025 by Nature for her groundbreaking research on cellular proteasomes and discovery of antimicrobial peptides, which could lead to advances in cancer immunotherapy, antimicrobial drugs, and disease diagnostics, despite facing setbacks like lab destruction during war.
The 19S regulatory particle, a component of the cellular proteasome machinery, has been found to have an independent role in regulating synaptic proteins at the synapses in the brain, according to a study published in Science. Using super-resolution imaging technique DNA PAINT, researchers discovered an abundance of free 19S particles interacting with synaptic proteins, suggesting a novel regulatory mechanism. This discovery may provide new targets for understanding and treating neurological diseases with dysfunctional synapses like dementia and Parkinson’s disease.
Cold temperatures activate a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging. The proteasome activator PA28γ/PSME3 mitigated the deficits caused by aging in both the nematode and in the human cells. Aging is a major risk factor for several neurodegenerative diseases associated with protein aggregation, including Alzheimer's, Parkinson's, Huntington's and ALS. The research was conducted at the University of Cologne's CECAD Cluster of Excellence in Aging Research.
Researchers at the University of California San Diego School of Medicine found that blood stem cells use an unexpected method to remove misfolded proteins, and that this pathway’s activity degrades with age. The study focused on hematopoietic stem cells (HSCs), the cells in our bone marrow that produce new blood and immune cells throughout our lives. The authors say boosting this specialized garbage disposal system called aggrephagy could help protect against age-related diseases.