Proteasome's New Role in Brain Synapses Unveiled.
The 19S regulatory particle, a component of the cellular proteasome machinery, has been found to have an independent role in regulating synaptic proteins at the synapses in the brain, according to a study published in Science. Using super-resolution imaging technique DNA PAINT, researchers discovered an abundance of free 19S particles interacting with synaptic proteins, suggesting a novel regulatory mechanism. This discovery may provide new targets for understanding and treating neurological diseases with dysfunctional synapses like dementia and Parkinson’s disease.