The Indian Pharmacopoeia Commission has warned that the widely used antibiotic Meropenem, manufactured by Pfizer and others, can cause severe adverse reactions such as Acute Generalized Exanthematous Pustulosis (AGEP). Doctors and patients are advised to monitor for these reactions and report any incidents. The drug is prescribed for various infections and is sold only under prescription.
Continuous administration of meropenem did not significantly decrease the composite of all-cause mortality and emergence of pandrug-resistant or extensively drug-resistant bacteria at day 28 compared to intermittent administration in critically ill patients with sepsis. The multicenter, double-blind, randomized clinical trial enrolled 607 patients and was conducted in 4 countries. The trial aimed to test the hypothesis that continuous administration of meropenem would decrease the composite outcome of new antimicrobial resistance and mortality.