Tag

Sepsis

All articles tagged with #sepsis

Dog lick sparks sepsis, UK woman faces quadruple amputation
health8 days ago

Dog lick sparks sepsis, UK woman faces quadruple amputation

Manjit Sangha, a 56-year-old Punjabi-origin woman from the West Midlands, fell critically ill last July after her family’s dog licked a minor wound; within 48 hours she was in a coma and doctors believe sepsis entered her bloodstream. She underwent quadruple amputations (both legs below the knee and both hands), lost her spleen, and battled pneumonia and gallstones. After 32 weeks in hospital she has returned home and is fundraising for advanced prosthetics, with over £22,000 raised so far. Medical experts say such infections are rare but can escalate rapidly.

Sepsis from a dog lick leaves UK woman with quadruple amputations
uk11 days ago

Sepsis from a dog lick leaves UK woman with quadruple amputations

Manjit Sangha, a 56-year-old pharmacy worker from Wolverhampton, spent 32 weeks in hospital fighting sepsis, surviving six cardiac arrests and pneumonia, after doctors suspect an infection from a dog licking a small wound. The ordeal resulted in the amputation of both hands and legs below the knee. Now home and together with her husband Kam, she is fundraising for advanced prosthetics, with GoFundMe and Screwfix workplace campaigns raising over $27,000 for robotic hands and related care.

Sepsis Forces Lisa McHugh to Postpone Return to Stage
entertainment19 days ago

Sepsis Forces Lisa McHugh to Postpone Return to Stage

Scottish-Irish country-pop star Lisa McHugh was rushed to the hospital with sepsis, forcing the postponement of her planned 2026 comeback concert in Letterkenny, Ireland, alongside Nathan Carter. She’s receiving treatment and focusing on recovery, following a recent health history that includes loss of use of her legs and diagnoses of Functional Neurological Disorder and Trigeminal Neuralgia.

Engineered Total Artificial Lung Bridges Patient to Double Lung Transplant
health1 month ago

Engineered Total Artificial Lung Bridges Patient to Double Lung Transplant

Northwestern researchers demonstrated a total artificial lung system (TAL) that temporarily replaces both diseased lungs for two days in a 33-year-old man with ARDS and sepsis, buying time for a successful double lung transplant; the patient recovered and is thriving two years later. TAL fully substitutes lung function and maintains heart stability, unlike ECMO, and while currently limited to specialized centers, the team envisions multicenter studies to refine protocols and expand use as a life-saving bridge to transplantation.

Methionine may blunt severe illness in animal tests, study suggests
health1 month ago

Methionine may blunt severe illness in animal tests, study suggests

New animal research indicates the essential amino acid methionine, when added to the diet, can protect against severe illness by dampening inflammation and improving kidney function in mice with infection-induced inflammation. The study found methionine boosted kidney filtration and reduced inflammatory damage without weakening the immune response. While researchers see potential for broader use in inflammatory diseases, results are early and human relevance is not yet established, warranting further investigation.

Court probes misdiagnosis in 20-year-old's death from flesh-eating infection
world1 month ago

Court probes misdiagnosis in 20-year-old's death from flesh-eating infection

A 20-year-old English amateur footballer, Luke Abrahams, died in January 2023 from sepsis and necrotizing fasciitis after doctors reportedly dismissed his symptoms as tonsillitis or sciatica; in the days leading to his death he interacted with multiple healthcare providers, including ambulance crews, who did not transfer him to hospital promptly. An inquest was opened in January 2023 at Northampton Coroner's Court, with his parents calling for accountability and a review of the care he received as investigations into the handling of his case continue.

Carbohydrate-Derived Sepsis Drug Shows Promise in Phase II Trial
health1 month ago

Carbohydrate-Derived Sepsis Drug Shows Promise in Phase II Trial

Griffith University researchers reported promising Phase II results for STC3141, a carbohydrate-based drug tested in 180 sepsis patients in China. The therapy aims to reverse organ damage by dampening a harmful inflammatory surge, rather than just treating symptoms. Grand Pharma plans a Phase III trial, with potential market a few years away.

Missed Red Flags Led to 20-Year-Old's Fatal Flesh-Eating Infection
health1 month ago

Missed Red Flags Led to 20-Year-Old's Fatal Flesh-Eating Infection

A 20-year-old English amateur footballer, Luke Abrahams of Northampton, died on Jan. 23, 2023 from sepsis and necrotizing fasciitis after doctors reportedly dismissed warning symptoms as tonsillitis and later sciatica; an inquest was opened and investigations found failures to escalate to hospital by medical staff and ambulance crews, prompting calls from his family for accountability.

Mother urges flu vaccination after daughter's death from flu complications
health1 month ago

Mother urges flu vaccination after daughter's death from flu complications

A 4-year-old girl died from flu complications after a co-infection with adenovirus led to pneumonia and sepsis. Her mother speaks out to urge other parents to vaccinate against the flu, noting CDC data showing pediatric flu deaths and that most of the affected children were not fully vaccinated, while doctors warn that flu can deteriorate quickly in children and emphasize vigilance for warning signs.

Age-Dependent FoxO1–Trim63 Axis Shapes Sepsis Outcomes in Mice
science1 month ago

Age-Dependent FoxO1–Trim63 Axis Shapes Sepsis Outcomes in Mice

In a polymicrobial sepsis mouse model, researchers show that aging alters disease tolerance rather than resistance: young mice rely on cardiac FoxO1 and its target Trim63 (MuRF1) to protect the heart and other organs, promoting survival, while in aged mice the same axis worsens organ damage and mortality. FoxO1 inhibition or Trim63 loss improves outcomes in aged animals but worsens them in young ones, demonstrating antagonistic pleiotropy and underscoring the need for age-tailored therapies in sepsis.