Tag

Genome Wide Association Study

All articles tagged with #genome wide association study

science6 days ago•26 min saved

Human genetics shape persistent Epstein-Barr virus control and autoimmune risk

A large-scale study using UK Biobank and All of Us genome data detects EBV reads in a subset of individuals, linking higher EBV load to HIV, immunosuppression, and smoking; GWAS identifies major associations in MHC/HLA and additional loci including ERAP2, with EBV load polygenic burden tied to multiple sclerosis (MHC class I) and rheumatoid arthritis (MHC class II) and overlaps with inflammatory diseases like IBD, hypothyroidism, and type 1 diabetes; proposes host-genome–derived markers of EBV persistence to guide future research and therapy.

via Nature|

#epstein-barr-virus #erap2 #genome-wide-association-study

science11 days ago•67 min saved

Host-gene signals point to gut physiology as main driver of microbiome diversity

A large GWAS of harmonized gut metagenomic data from 16,017 Swedish adults with replication in 12,652 Norwegians identifies host genetic variants linked to microbiome richness and 149 species; the strongest signal at OR51E1–OR51E2 suggests enteroendocrine fatty acid sensing shapes microbial communities, with additional loci near mucin genes and bile-acid pathways. Mendelian randomization links some taxa to LDL cholesterol and BMI-related traits, underscoring gastrointestinal physiology as a key driver of microbiome variation. Limitations include European-ancestry focus and challenges in pinpointing causal genes.

via Nature|

#enteroendocrine-cells #genome-wide-association-study #gut-microbiome

health6 months ago•4 min saved

Genetic research confirms biological basis of ME/CFS

A large genetic study called DecodeME identified eight new genetic regions linked to ME/CFS, providing the first robust evidence of genetic contributions to the syndrome, which affects millions worldwide and involves immune and nervous system dysfunction. The study analyzed over 15,000 patients of European ancestry, highlighting potential biological pathways involved in the disease, though further research is needed to develop diagnostics or treatments.

via Live Science|

#decodeme #genetics #genome-wide-association-study

health-genetics2 years ago•4 min saved

"Predicting Type 2 Diabetes Risk: Insights from Genetic and Epigenetic Research"

The largest genome-wide association study of type 2 diabetes to date has identified new genetic risk factors and clusters of variants that contribute to the disease, shedding light on different mechanisms underlying the condition. The study included data from over 2.5 million individuals and revealed 1,289 genetic variants, 145 of which were new discoveries. Researchers also found that certain genetic clusters were associated with specific cardiometabolic traits and could predict cardiovascular outcomes in individuals with type 2 diabetes. This research represents a significant advancement in understanding the genetic basis of type 2 diabetes and may lead to improved treatments and care for individuals with the condition in the future.

via Medical News Today|

#cardiovascular-disease #genetic-risk-factors #genome-wide-association-study

health2 years ago•27 min saved

17 Genetic Loci Linked to Nonalcoholic Fatty Liver Disease Identified in Meta-Analysis

A genome-wide association meta-analysis has identified 17 genetic loci associated with nonalcoholic fatty liver disease (NAFLD). The study analyzed data from over 1.1 million individuals of diverse ancestries and found genetic variants that influence the risk of NAFLD, providing insights into the underlying biology of the disease. The findings highlight the importance of genetic factors in the development of NAFLD and may lead to improved understanding, prevention, and treatment of this common liver disorder. Data from the study is publicly available for further research.

via Nature.com|

#data-availability #genetic-variants #genome-wide-association-study

health2 years ago•3 min saved

Higher Alzheimer's risk for Ashkenazi Jews, study shows

A recent study by Boston University’s Chobanian & Avedisian School of Medicine found that Ashkenazi Jews are more likely to suffer from Alzheimer's disease due to their genetic makeup. The study conducted a genome-wide association study for AD in a sample of 3,500 people whose ancestry was almost exclusively Ashkenazi Jewish, identifying several genetic risk factors for AD, including some previously known and several novel ones that are strong biological candidates. The findings may lead to the development of novel AD biomarkers and therapeutic targets.

via The Jerusalem Post|

#alzheimers-disease #ashkenazi-jews #genetic-research

health2 years ago•2 min saved

Ashkenazi Jews have unique genetic risk for Alzheimer's disease

Researchers have identified several new genetic risk factors for Alzheimer’s disease unique to Ashkenazi Jews through a genome-wide association study. The study found that some AD susceptibility variants are more frequent in this group compared to much larger and more genetically heterogeneous EA cohorts. The researchers identified several genetic risk factors for AD including some previously known and several novel ones that are strong biological candidates. The findings may lead to the development of novel AD biomarkers and therapeutic targets.

via Futurity: Research News|

#alzheimers-disease #ashkenazi-jews #genetic-risk-factors

science2 years ago•4 min saved

Neanderthal Gene Shapes Modern Human Noses.

A new genome-wide association study (GWAS) from University College London (UCL) and collaborators has found that genetic material inherited from Neanderthals can affect the nose shape of modern humans. The study explored genetic markers associated with specific human facial features in over 6,000 Latin Americans and identified one specific genome region associated with nose shape that carries genetic material inherited from the Neanderthals. The research team collected 2D photographs from over 6,000 volunteers involved in the CANDELA study, all of whom have been previously studied in GWASs exploring physical traits.

via Technology Networks|

#genetics #genome-wide-association-study #latin-americans