Tag

Genome Synthesis

All articles tagged with #genome synthesis

science1 month ago•27 min saved

AI writes life: scientists glimpse a post-Darwinian biotech era

Scientists are using AI to design entire genomes and to craft new viruses, signaling a post-Darwinian era where life can be authored. Stanford and Caltech demonstrations show AI-driven genome design (EvoΦ2147 and Evo2) and DNA-synthesis tools (Sidewinder) that could accelerate vaccines, cancer therapies, and other biotechnologies, while raising serious security, ethical, and governance concerns that require safeguards and policy frameworks.

via The Times|

#ai #genome-synthesis #governance

science-and-technology7 months ago•1 min saved

Scientists Initiate Project to Synthesize Human Chromosome and Genome

A new project aims to synthesize a human chromosome, marking progress in synthetic biology and genome engineering, building on the completion of the human genome sequence in 2022.

via The Economist|

#crispr #dna-sequencing #genome-synthesis

science-and-technology7 months ago•3 min saved

UK Scientists Begin Synthesizing Human Genome to Explore DNA Function

Scientists are beginning work on the Synthetic Human Genome project, aiming to digitally design and synthesize a large portion of human DNA, which could revolutionize medicine and biotechnology, though ethical and technical challenges remain.

via ScienceAlert|

#biotechnology #ethics #genome-synthesis

science8 months ago•3 min saved

Scientists Begin Creating Human DNA from Scratch Amid Controversy

A UK-based research team, funded by the Wellcome Trust with $11.7 million, is pioneering the creation of a human genome from scratch, aiming to deepen understanding of genetics and develop new medical treatments, while actively addressing the ethical implications of such technology.

via Gizmodo|

#biotechnology #ethical-issues #genome-synthesis

science-and-technology2 years ago•72 min saved

"Revolutionizing Disease Research: Mouse Genome Rewriting Unlocks New Disease Models"

Scientists have developed a novel mammalian genome writing method called mSwAP-In, which allows for large-scale, scarless, and iterative genome writing in mouse embryonic stem cells. Using this method, they successfully engineered a synthetic version of the Trp53 gene and fully humanized the ACE2 gene in mouse models. The humanized ACE2 mice were susceptible to SARS-CoV-2 infection and exhibited a more accurate representation of COVID-19 pathology compared to existing transgenic models. This genome writing technique has the potential to bridge human-mouse evolutionary gaps and improve our understanding of human diseases.

via Nature.com|

#ace2 #covid-19 #genetic-engineering

scientific-research2 years ago•26 min saved

Efficient Tools for Continuous Megabase-Scale Genome Assembly

Researchers have developed a method for continuous synthesis of E. coli genome sections and assembly of Mb-scale human DNA. The study provides detailed data availability, including sequences, design details, and code used in the experiments. The research builds upon previous work in genome recoding and large-scale genome rearrangement, offering potential applications in synthetic biology and genetic engineering.

via Nature.com|

#code-availability #dna-assembly #e-coli