All articles tagged with #genome synthesis
Originally Published 6 months ago — by The Economist
A new project aims to synthesize a human chromosome, marking progress in synthetic biology and genome engineering, building on the completion of the human genome sequence in 2022.
Originally Published 6 months ago — by ScienceAlert
Scientists are beginning work on the Synthetic Human Genome project, aiming to digitally design and synthesize a large portion of human DNA, which could revolutionize medicine and biotechnology, though ethical and technical challenges remain.
Originally Published 6 months ago — by Gizmodo
A UK-based research team, funded by the Wellcome Trust with $11.7 million, is pioneering the creation of a human genome from scratch, aiming to deepen understanding of genetics and develop new medical treatments, while actively addressing the ethical implications of such technology.
Originally Published 2 years ago — by Nature.com
Scientists have developed a novel mammalian genome writing method called mSwAP-In, which allows for large-scale, scarless, and iterative genome writing in mouse embryonic stem cells. Using this method, they successfully engineered a synthetic version of the Trp53 gene and fully humanized the ACE2 gene in mouse models. The humanized ACE2 mice were susceptible to SARS-CoV-2 infection and exhibited a more accurate representation of COVID-19 pathology compared to existing transgenic models. This genome writing technique has the potential to bridge human-mouse evolutionary gaps and improve our understanding of human diseases.
Originally Published 2 years ago — by Nature.com
Researchers have developed a method for continuous synthesis of E. coli genome sections and assembly of Mb-scale human DNA. The study provides detailed data availability, including sequences, design details, and code used in the experiments. The research builds upon previous work in genome recoding and large-scale genome rearrangement, offering potential applications in synthetic biology and genetic engineering.