New Pathway for β-Hydroxybutyrate in Cancer Cell Metabolism
TL;DR Summary
The study reveals that cancer cells can produce cytosolic acetyl-CoA from β-hydroxybutyrate (β-OHB) via two pathways: the mitochondrial citrate-dependent route involving OXCT1 and a citrate-independent route involving AACS, supporting tumor growth especially under nutrient-limited conditions.
Topics:science#b-hydroxybutyrate#biology#cancer-metabolism#cytosolic-acetyl-coa#ketone-pathways#tumor-growth
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