All articles tagged with #inverse vaccine
Scientists have developed a promising approach using engineered regulatory T cells as an 'inverse vaccine' to potentially treat celiac disease, showing success in mice by reducing immune reactions to gluten, though further research is needed.
This week in science news, the James Webb Space Telescope made several exciting discoveries, including capturing an image of an "Einstein ring" and finding an ancient supernova. Scientists are also testing an "inverse vaccine" that successfully treated a multiple sclerosis-like condition in mice. In other news, a lost language was discovered on an ancient clay tablet in Turkey, and a reconstruction of a young woman from the Bronze Age reveals what she may have looked like.
Inverse vaccines, which work by instructing the immune system to leave certain cells alone, may hold the key to treating autoimmune disorders such as multiple sclerosis, Type 1 diabetes, and celiac disease. Researchers at the University of Chicago have developed a method to deliver a message to T and B cells, telling them what not to destroy. In lab tests, the inverse vaccine successfully halted the destruction of myelin sheath on nerve cells in mouse models of multiple sclerosis. Clinical trials for celiac disease have already been conducted, and trials for multiple sclerosis are currently underway.
An "inverse vaccine" approach using ANK-700, which teaches the immune system not to attack specific targets, has shown promise in reducing disease activity in mouse models of multiple sclerosis (MS). The vaccine works by inducing immune tolerance, preventing the immune system from attacking the myelin sheath in the brain and spinal cord. ANK-700 is currently being tested in early clinical trials for MS treatment, with the potential to provide disease control without impairing the immune system's ability to defend against infections.
Researchers at the University of Chicago's Pritzker School of Molecular Engineering have developed an "inverse vaccine" that has shown promise in reversing autoimmune diseases such as multiple sclerosis, type 1 diabetes, and Crohn's disease. Unlike traditional vaccines that teach the immune system to attack pathogens, this new vaccine removes the immune system's memory of a specific molecule, preventing autoimmune reactions. By coupling an antigen with a molecule that resembles a fragment of an aged cell, the vaccine triggers the liver to mark the antigen as a friend rather than a foe, effectively stopping the autoimmune response. The vaccine has successfully reversed symptoms in animal models and is currently undergoing safety trials in humans.