All articles tagged with #intestinal stem cells
Transferring gut microbes from young to aged mice rejuvenates the gut by reactivating intestinal stem cells, restoring crypt-villi structure and barrier function, and reducing inflammatory gene expression. The effects are mediated by microbial metabolites such as indole-3-aldehyde and butyrate, with Akkermansia muciniphila enrichment linked to the benefits.
Dietary cysteine enhances intestinal stem cell function by promoting CD8+ T cell-derived IL-22, which supports intestinal regeneration and homeostasis.
New research in mice suggests that bacteria in the digestive tract can break down ingested carbon nanomaterials, leading to changes in the microbiome. The breakdown of these nanoparticles can also result in excessive amounts of fatty acids, which may inhibit the normal function of intestinal stem cells. This raises concerns about the potential effects of accidental ingestion of nanomaterials in consumer products on human health.