Young Microbes Reboot Aging Gut by Reviving Stem Cells
TL;DR Summary
Transferring gut microbes from young to aged mice rejuvenates the gut by reactivating intestinal stem cells, restoring crypt-villi structure and barrier function, and reducing inflammatory gene expression. The effects are mediated by microbial metabolites such as indole-3-aldehyde and butyrate, with Akkermansia muciniphila enrichment linked to the benefits.
Topics:health#aging#fecal-microbiota-transplant#gut-barrier#intestinal-stem-cells#microbiome#science
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