
Menopause Tied to Brain Changes, Sleep Disturbances, with Limited HRT Mood Benefits
A Cambridge-led study using UK Biobank data links menopause to reduced grey-matter volume in key brain regions (hippocampus, entorhinal cortex, anterior cingulate) and to higher anxiety, depression, and sleep problems. Hormone replacement therapy does not prevent these brain or mood changes, though it may slow the decline in reaction times; memory tasks showed no major deficits. Postmenopausal women also reported more sleep issues and greater tiredness, and those on HRT had similar sleep duration but felt more fatigued. The findings raise questions about dementia risk given the regions affected and suggest the benefits of healthy lifestyle during menopause.




