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Click Chemistry

All articles tagged with #click chemistry

science22 hours ago•56 min saved

Robot‑assisted chemistry spots metal‑based antibiotics, with iridium as a standout

Researchers used a liquid‑handling robot to perform click chemistry, creating 672 metal complexes by combining 192 ligands with five metals. Screening revealed notable antibacterial activity for iridium and rhenium complexes against Staphylococcus aureus, with six compounds selected for further study. One iridium complex showed 50–100× higher activity against bacteria than toxicity to human cells, a promising sign for metal‑based antibiotics but requiring further drug‑like optimization and in‑vivo testing; AI and expanded libraries are planned to guide next steps.

via Live Science|

#antibiotics #click-chemistry #iridium

science2 years ago•0 min saved

Premature Announcement: 2023 Nobel Prize in Chemistry Winners Revealed

The recipient of the 2023 Nobel Prize in chemistry will be announced on October 4th, following last year's award to three scientists for their work on click chemistry.

via PBS NewsHour|

#2023 #announcement #chemistry

science-and-technology2 years ago•2 min saved

"Revolutionary New Reaction Unveiled in Click Chemistry Research"

Chemists John Moses and Barry Sharpless have developed a new technique called phosphorus fluoride exchange (PFEx) that enables scientists to easily build oxygen and nitrogen-linked products from a central phosphorus hub. The PFEx reaction is done under mild conditions and operates orthogonally to other click reactions, allowing the new technique to function harmoniously alongside established reactions. The researchers hope that greater diversity in clicked molecules will lead to discoveries, including new bioactive molecules.

via Chemistry World|

#bioactive-molecules #chemical-synthesis #click-chemistry

science-and-technology2 years ago•3 min saved

Biology's Favorite Chemical: A Key Tool for Scientists.

Scientists have developed a new technique called phosphorus fluoride exchange (PFEx), which uses phosphorous as a chemical connector to construct complex molecules, expanding the realm of click chemistry. This advancement could potentially contribute to the discovery of effective cancer therapeutics and the creation of new materials with beneficial properties like flame retardance or antimicrobial effects, while maintaining environmental sustainability as phosphorous bonds can be broken down easily during recycling.

via SciTechDaily|

#cancer-therapeutics #chemistry #click-chemistry