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Zosurabalpin

All articles tagged with #zosurabalpin

health-medicine2 years ago

"Breakthrough Antibiotic Kills Drug-Resistant Superbugs in Trials"

Researchers have discovered a new class of antibiotic, zosurabalpin, which effectively kills the deadly drug-resistant superbug, carbapenem-resistant Acinetobacter baumannii (Crab). Zosurabalpin works by blocking a molecular machine that transports a toxin used by Crab, causing the bacteria to die. While the antibiotic is currently in phase 1 clinical trials, it shows promise in combating antibiotic-resistant infections and reducing the emergence of resistance.

via ScienceAlert|
#antibiotic-development#antibiotics#drug-resistance
health-and-medicine2 years ago

"Zosurabalpin: A New Antibiotic Breakthrough Battles Drug-Resistant Superbugs"

Swiss scientists have discovered a new antibiotic, zosurabalpin, which is effective against drug-resistant gram-negative bacteria, specifically targeting Acinetobacter baumannii. This breakthrough, the first in over 50 years, could combat the growing issue of antimicrobial resistance, which is responsible for millions of deaths annually. Zosurabalpin operates by blocking the bacteria's ability to form a protective outer membrane, leading to its death. Currently in phase 1 clinical trials, this discovery opens the door to potentially treating a range of drug-resistant infections and is a significant step forward in the fight against the "silent pandemic" of antibiotic resistance.

via New York Post |
##acinetobacterbaumannii#antibioticresistance
health-and-medicine2 years ago

"Breakthrough Antibiotic Zosurabalpin Targets Drug-Resistant Superbugs"

Swiss scientists have discovered a new antibiotic, zosurabalpin, which is effective against drug-resistant gram-negative bacteria, particularly Acinetobacter baumannii. This antibiotic works by blocking the lipopolysaccharide (LPS) responsible for the bacteria's protective outer membrane, causing the bacteria to die. Zosurabalpin represents the first new class of antibiotic against these bacteria in over 50 years and is currently undergoing phase 1 clinical trials. The breakthrough is significant as antimicrobial resistance is projected to cause more deaths than cancer in the next 30 years, and this discovery could lead to the development of more drugs to combat resistant bacteria.

via Fox News|
##acinetobacterbaumannii#antibioticresistance
health-and-medicine2 years ago

"Breakthrough Antibiotic Offers Hope Against Drug-Resistant Superbugs"

Researchers at Harvard University and Roche have developed an experimental antibiotic named zosurabalpin that effectively kills the drug-resistant superbug Acinetobacter baumannii. This breakthrough represents a new class of drugs, as it targets Gram-negative bacteria, which are notoriously difficult to treat due to their complex membrane structures and resistance strategies. Zosurabalpin, which is already in clinical trials, works by clogging a transport system in the bacteria, leading to lethal toxicity. This discovery is significant as it offers hope against infections with mortality rates of 40 to 60 percent and could lead to more treatments for drug-resistant infections.

via Ars Technica|
##acinetobacterbaumannii#antibioticresistance
health-and-medicine2 years ago

"Promising New Antibiotic Class Emerges in Battle Against Drug-Resistant Superbugs"

Scientists have discovered a new class of antibiotic named Zosurabalpin, which has proven effective against the drug-resistant superbug CRAB (Carbapenem-resistant Acinetobacter baumannii) in lab tests and mouse models. CRAB is a critical pathogen with a high mortality rate, and the new antibiotic works by disrupting the bacteria's protective membrane. While promising, Zosurabalpin's effectiveness in humans has yet to be confirmed through clinical trials. This breakthrough could potentially address the growing global health threat of antimicrobial resistance, which causes over 1 million deaths annually.

via Daily Mail|
##antibioticresistance#crab
health-and-medicine2 years ago

"Breakthrough Antibiotic Offers New Hope Against Superbugs"

A potential new antibiotic, zosurabalpin, has shown promise in treating lethal hospital infections caused by the drug-resistant Acinetobacter baumannii, a priority-one critical pathogen. Prof Laura Piddock from the Global Antibiotic Research and Development Partnership reported that the compound disrupts the bacterium's protective membrane, proving effective in lab and mouse studies. Although "first-in-man" studies have been conducted, extensive clinical trials and economic considerations remain before the drug can be widely used in hospitals. Despite the challenges, the discovery offers hope for treating various hard-to-treat infections.

via BBC.com|
#acinetobacter-baumannii#antibiotics#clinical-trials
health-and-medicine2 years ago

"Revolutionary Antibiotic Emerges to Combat Drug-Resistant Superbugs"

Researchers have developed a new class of antibiotics, tethered macrocyclic peptides (MCPs), targeting the lipopolysaccharide (LPS) transporter in bacteria, specifically inhibiting the LptB2FGC complex. The clinical candidate, zosurabalpin (RG6006), has shown potent activity against carbapenem-resistant Acinetobacter baumannii (CRAB), a critical pathogen with limited treatment options. This novel antibiotic class effectively treats drug-resistant bacterial infections in vitro and in mouse models, representing a significant advancement in combating antibiotic resistance and providing a new treatment option for invasive CRAB infections.

via Nature.com|
#acinetobacter-baumannii#antibiotic-resistance#health-and-medicine
health-and-medicine2 years ago

"Breakthrough Antibiotic Emerges to Combat Superbugs with Unprecedented Resistance-Fighting Method"

Researchers have developed a new antibiotic called Zosurabalpin, which shows promise in treating drug-resistant Acinetobacter baumannii, a deadly bacteria responsible for serious infections and high mortality rates. This novel antibiotic, which is now in phase 1 clinical trials, operates by disrupting the bacteria's outer membrane, a method that could potentially be applied to other resistant Gram-negative bacteria. The breakthrough comes after a 50-year gap since the last class of antibiotics was approved to combat such pathogens, offering hope in the global fight against antimicrobial resistance.

via CNN|
##acinetobacterbaumannii#antibioticresistance
health-and-medicine2 years ago

"Revolutionary Antibiotic Emerges as Hope Against Drug-Resistant Superbugs"

Researchers have discovered a new antibiotic, zosurabalpin, that shows promise in fighting the drug-resistant superbug Acinetobacter baumannii (CRAB). This new compound disrupts the transport of a key bacterial toxin to the outer membrane, a novel approach not seen in other FDA-approved antibiotics. While the drug has been effective in mouse studies and is currently in Phase I human trials, scientists caution that bacteria may eventually develop resistance to this new antibiotic as well. The development of zosurabalpin represents a significant breakthrough in the ongoing battle against multidrug-resistant bacteria.

via Los Angeles Times|
#acinetobacter-baumannii#antibiotic-resistance#drug-development