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Acinetobacter Baumannii

All articles tagged with #acinetobacter baumannii

health-and-medicine2 years ago

"Breakthrough Antibiotic Offers New Hope Against Superbugs"

A potential new antibiotic, zosurabalpin, has shown promise in treating lethal hospital infections caused by the drug-resistant Acinetobacter baumannii, a priority-one critical pathogen. Prof Laura Piddock from the Global Antibiotic Research and Development Partnership reported that the compound disrupts the bacterium's protective membrane, proving effective in lab and mouse studies. Although "first-in-man" studies have been conducted, extensive clinical trials and economic considerations remain before the drug can be widely used in hospitals. Despite the challenges, the discovery offers hope for treating various hard-to-treat infections.

via BBC.com|
#acinetobacter-baumannii#antibiotics#clinical-trials
health-and-medicine2 years ago

"Revolutionary Antibiotic Emerges to Combat Drug-Resistant Superbugs"

Researchers have developed a new class of antibiotics, tethered macrocyclic peptides (MCPs), targeting the lipopolysaccharide (LPS) transporter in bacteria, specifically inhibiting the LptB2FGC complex. The clinical candidate, zosurabalpin (RG6006), has shown potent activity against carbapenem-resistant Acinetobacter baumannii (CRAB), a critical pathogen with limited treatment options. This novel antibiotic class effectively treats drug-resistant bacterial infections in vitro and in mouse models, representing a significant advancement in combating antibiotic resistance and providing a new treatment option for invasive CRAB infections.

via Nature.com|
#acinetobacter-baumannii#antibiotic-resistance#health-and-medicine
health2 years ago

"Emerging Antibiotic Class Offers Hope Against Drug-Resistant Superbugs Amid Economic Challenges"

Researchers have discovered a new class of antibiotics, including a compound named zosurabalpin, that shows promise against the drug-resistant bacterium Acinetobacter baumannii. However, the economic model for antibiotic development is flawed, with high costs and low returns deterring pharmaceutical companies. Governments are encouraged to adopt a mix of 'push' and 'pull' incentives to stimulate antibiotic research and development. The UK's 'subscription' model and the proposed PASTEUR Act in the US are examples of efforts to address this issue. The upcoming UN General Assembly meeting on antimicrobial resistance presents an opportunity for countries to commit to action, as the threat of resistant bacteria like A. baumannii continues to grow.

via Nature.com|
#acinetobacter-baumannii#antibiotics#antimicrobial-resistance
health-and-medicine2 years ago

"Revolutionary Antibiotic Emerges as Hope Against Drug-Resistant Superbugs"

Researchers have discovered a new antibiotic, zosurabalpin, that shows promise in fighting the drug-resistant superbug Acinetobacter baumannii (CRAB). This new compound disrupts the transport of a key bacterial toxin to the outer membrane, a novel approach not seen in other FDA-approved antibiotics. While the drug has been effective in mouse studies and is currently in Phase I human trials, scientists caution that bacteria may eventually develop resistance to this new antibiotic as well. The development of zosurabalpin represents a significant breakthrough in the ongoing battle against multidrug-resistant bacteria.

via Los Angeles Times|
#acinetobacter-baumannii#antibiotic-resistance#drug-development
health2 years ago

"Breakthrough Treatment Unveiled to Tackle Hospital Superbug"

Researchers at Cal State Fullerton have discovered a promising new therapeutic to treat Acinetobacter baumannii, a superbug commonly found in hospitals and resistant to many antibiotics. They found that a strain of lactic acid bacteria called Lacticaseibacillus rhamnosus CRL 2244 was effective at stopping the growth of A. baumannii and even causing the bacteria to die. This finding could provide a new alternative treatment for carbapenem-resistant Acinetobacter baumannii infections. Further research is needed to explore this potential treatment option.

via Phys.org|
#acinetobacter-baumannii#antibiotic-resistance#health
health2 years ago

AI-assisted discovery of new antibiotic effective against superbug

Researchers from McMaster University and MIT have used an AI algorithm to discover a new antibiotic, abaucin, which could potentially eradicate the superbug Acinetobacter baumannii, a serious threat to human health. The AI model was trained to predict the antibacterial potential of new molecules, streamlining the drug discovery process and enabling researchers to focus on the most promising candidates. The AI analysis generated several hundred compounds worthy of consideration, and 240 of these compounds underwent rigorous laboratory testing to evaluate their efficacy. The application of AI algorithms in this manner marks a significant leap forward in the field of drug development, offering a more efficient and targeted approach to combating antibiotic-resistant superbugs.

via News18|
#acinetobacter-baumannii#ai#antibiotic
health2 years ago

AI Supercomputer Discovers Antibiotic to Combat Deadly Superbug

An antibiotic molecule that can kill Acinetobacter baumannii, one of the most dangerous antibiotic-resistant bacteria, has been discovered by Canadian and US scientists using AI. The newly discovered compound, abaucin, was proven effective in experiments on mice with infected wounds and bacterial cells grown in the lab. The AI process used could also speed the discovery of treatments for other potentially fatal diseases, including MRSA, because it can access hundreds of millions, possibly billions, of molecules that have potential antibacterial properties.

via Good News Network|
#acinetobacter-baumannii#ai#antibiotic-resistance
health2 years ago

AI-assisted discovery of new antibiotic to combat drug-resistant superbugs

Researchers from MIT and McMaster University have used AI technology to identify a new antibiotic named abaucin, effective against Acinetobacter baumannii, a hospital-borne, drug-resistant bacteria. The drug, discovered through a machine-learning model, is significant due to its narrow-spectrum efficacy and unique mechanism of disrupting lipoprotein trafficking within bacterial cells. The researchers identified the new drug from a library of nearly 7,000 potential drug compounds using a machine-learning model that they trained to evaluate whether a chemical compound will inhibit the growth of A. baumannii.

via SciTechDaily|
#acinetobacter-baumannii#ai#antibiotics
health2 years ago

AI discovers new antibiotics to combat drug-resistant superbugs.

Scientists from McMaster University and the Massachusetts Institute of Technology have discovered a new antibiotic, abaucin, that can kill the deadly hospital superbug Acinetobacter baumannii using an AI algorithm to screen thousands of antibacterial molecules. The bacteria pose a threat to hospitals, nursing homes, and patients who require ventilators and blood catheters. The AI method affords the opportunity to vastly increase the rate at which new antibiotics are discovered, and at a reduced cost.

via The Guardian|
#acinetobacter-baumannii#ai#antibiotic