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Synaptic Dysfunction

All articles tagged with #synaptic dysfunction

"Protein Discovery Offers Potential Alzheimer's Synapse Repair Solution"

Originally Published 1 year ago — by Medical Xpress

Scientists have discovered a potential way to repair synapses damaged in Alzheimer's disease by focusing on the protein KIBRA, which is found in the brain and is crucial for synaptic function. The study proposes an alternate strategy for reversing the memory problems associated with Alzheimer's disease and related dementias, aiming to restore memory by targeting the damage caused by the disease rather than reducing toxic proteins in the brain. The research suggests that KIBRA could be used as a biomarker of synaptic dysfunction and cognitive decline, and a therapy based on this protein has shown promise in reversing memory impairment in laboratory mice with a condition mimicking human Alzheimer's disease. This approach could complement existing and future treatments by repairing synapses and improving their function.

health health alzheimers-disease health kibra memory-loss synapses synaptic-dysfunction

Unveiling a Paradigm Shift: New Insights into Parkinson's Disease

Originally Published 2 years ago — by Medical News Today

A recent study suggests that synaptic dysfunction may be an initial trigger for Parkinson's disease, occurring before the death of dopaminergic neurons. Researchers discovered that the interaction of two genes, PINK1 and parkin, disrupts the function of synapses, leading to the accumulation of toxic oxidized dopamine. This finding opens up new treatment avenues, as targeting the synapses could potentially prevent damage to the neurons and slow the progression of the disease. The study highlights the importance of intervening early, before neurons degenerate, to address synaptic dysfunction in Parkinson's disease.

health health genetic-mutations health neurodegenerative-disorder parkinsons-disease synaptic-dysfunction treatment-strategies