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Single Cell Atlas

All articles tagged with #single cell atlas

science6 days ago•7 min saved

Aging Decoded: 7-Million-Cell Atlas Maps Coordinated Decline Across 21 Organs

Researchers mapped nearly 7 million cells from 21 mouse organs at three ages to create the most detailed aging atlas yet, finding that aging proceeds in a synchronized, body-wide fashion with about a quarter of cell types changing in abundance and notable sex differences; the study also identified shared DNA-regulatory hotspots and cytokine-linked changes that could become targets for therapies aiming to slow aging across multiple organs.

via ScienceDaily|

#aging #anti-aging-therapy #epigenomics

health-and-science2 years ago•2 min saved

"Unveiling the Placental Microcosm: Single-Cell Atlas of Term Labor"

Researchers supported by the NIH have created a single-cell atlas of the placenta during term labor, offering insight into the communication between maternal and fetal cells during childbirth. The atlas, based on samples from 42 term pregnancies, reveals changes in gene expression patterns among different cell types and identifies cells most affected by labor in the chorioamniotic membranes. The study also suggests that placental biomarkers present in maternal blood may be used to identify pregnancies at risk for preterm birth, although further validation is needed.

via National Institutes of Health (.gov)|

#health-and-science #nih #placenta

science-and-technology2 years ago•3 min saved

Decoding the Intricacies of Human Limb Development: Unveiling Growth Processes and Birth Syndromes

Scientists have created the first human cell atlas of early limb development, revealing in exquisite detail how fingers and toes grow. By analyzing thousands of single cells from donated embryonic tissues, the researchers mapped gene expression patterns and identified distinct cell clusters involved in limb development. They found that the process is highly complex and precisely regulated, resembling a sculptor chiseling away at a block of marble. The study deepens our understanding of how anatomically complex structures form and has implications for research and healthcare. The researchers also showed that limb formation in humans and mice follows similar trajectories, with some differences in activated genes and cell types.

via ScienceAlert|

#embryonic-development #gene-expression #human-development