All articles tagged with #epigenomics
A large-scale study reveals that Alzheimer's disease involves fundamental breakdowns in epigenomic control within brain cells, leading to gene expression dysregulation and cognitive decline, suggesting new treatment avenues targeting genome stability.
This study provides a comprehensive single-cell epigenomic atlas of human subcutaneous adipose tissue, revealing cell-type-specific DNA methylation, chromatin conformation, and gene expression patterns, and their implications for obesity-related genetic risks and regulatory mechanisms.
Researchers have created a comprehensive atlas of the adult mouse brain, mapping the DNA methylome and 3D genome at single-cell resolution. The study utilized enhanced single-nucleus methylation sequencing and chromatin conformation capture sequencing to analyze DNA methylomes and the 3D genome in detail. The dataset identified 4,673 cell groups and provided a multi-omic resource for understanding the molecular architecture of the mouse brain. The study deepens insights into the epigenetic and transcriptomic intricacies that underpin brain function and diseases.