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Short Chain Fatty Acids

All articles tagged with #short chain fatty acids

Host-gene signals point to gut physiology as main driver of microbiome diversity
science11 days ago

Host-gene signals point to gut physiology as main driver of microbiome diversity

A large GWAS of harmonized gut metagenomic data from 16,017 Swedish adults with replication in 12,652 Norwegians identifies host genetic variants linked to microbiome richness and 149 species; the strongest signal at OR51E1–OR51E2 suggests enteroendocrine fatty acid sensing shapes microbial communities, with additional loci near mucin genes and bile-acid pathways. Mendelian randomization links some taxa to LDL cholesterol and BMI-related traits, underscoring gastrointestinal physiology as a key driver of microbiome variation. Limitations include European-ancestry focus and challenges in pinpointing causal genes.

Gut Microbes: The Secret to Human Brain Evolution
science1 year ago

Gut Microbes: The Secret to Human Brain Evolution

A new study suggests that the gut microbiome may have played a crucial role in the evolution of larger brains in primates, including humans. Researchers found that gut microbes from larger-brained primates, such as humans and squirrel monkeys, helped convert food into energy for the brain more efficiently than those from smaller-brained primates. This process may have driven hosts to consume more food, channeling excess energy to the brain. However, the study, conducted on mice, requires further research to confirm these findings and understand the exact mechanisms involved.

Exploring the Benefits of Postbiotics for Gut Health
health2 years ago

Exploring the Benefits of Postbiotics for Gut Health

Postbiotics are the metabolites generated after the digestion of prebiotics and fiber-rich compounds by probiotics and our gut's resident microbiota. They can provide similar benefits to probiotics and prebiotics without any side effects. Postbiotics can shift our gut microbiome towards a healthy composition, stimulate our immune system, and lower the risk of colon cancer. Consuming probiotic-containing foods like yogurt and sauerkraut and prebiotic-rich plant foods can help harness the benefits of postbiotics.

Gut Bacteria Key to Liver Regeneration.
health2 years ago

Gut Bacteria Key to Liver Regeneration.

Researchers at the Technical University of Munich have found that gut bacteria play a crucial role in the liver's regenerative capacity. Short-chain fatty acids produced by gut bacteria are essential for liver cell growth and division. Antibiotics disrupt the microbiome and delay liver regeneration. The study suggests that physicians could examine patients' gut bacteria to determine whether conditions are favorable for surgery or whether it is better to wait for the microbiome to recover.