Tag

Multi Omics

All articles tagged with #multi omics

science1 month ago•6 min saved

Aging Revealed: Two Midlife Turning Points at 44 and 60

A Stanford-led study analyzing 135,000 molecular markers in 108 people finds aging may occur at two discrete inflection points—around ages 44 and 60—where rapid changes occur in cardiovascular, immune, and metabolic pathways, with microbiome shifts closely linked to these transitions. While causality isn’t established, the results suggest midlife biology could influence disease risk and screening strategies, potentially guiding precision medicine. Limitations include a small, non-diverse sample and observational data; lifestyle factors like stress and alcohol may also play a role in these transitions.

via The Daily Galaxy|

#aging #biology #microbiome

science1 month ago•97 min saved

One-carbon metabolism orchestrates multi-tissue metabolic reprogramming in cancer cachexia

Multi-omics profiling across eight tissues in cachexia-bearing mice reveals a coordinated metabolic shift centered on one-carbon metabolism, linked to inflammation, glucose hypermetabolism and muscle atrophy; the pattern recapitulates across five cancer models and a humanized cachexia model, offering a systemic framework for tumor–host metabolic reprogramming and potential intervention targets.

via Nature|

#cancer-cachexia #metabolomics #multi-omics

science2 years ago•102 min saved

"Conserved Microbial Network Unveils Clues for Forensic Science"

Researchers have discovered a universal network of microbes that respond to cadaver decomposition, despite variations in climate, location, and season. The study used multi-omic data to reveal that a conserved interdomain soil microbial decomposer network assembles in response to mammalian remains, with evidence of increased metabolic efficiencies to process lipid- and protein-rich compounds. Key members of the microbial decomposer network are associated with various mammalian carrion, suggesting that they are not human-specific. The findings have implications for forensic science, agriculture, sustainability, and the human death care industry.

via Nature.com|

#cadaver #decomposition #microbial-ecology

science2 years ago•4 min saved

Mapping the Complex World of DNA Repair in Cells.

Scientists at the University of California San Diego School of Medicine have created a new map that shows the complex system of DNA damage response (DDR) in the human body. DDR is a network of cell-cycle checkpoints and DNA damage repair tools that help maintain the integrity of the genome and support normal functioning and health. The new map, which uses multi-omics and machine learning, shows a hierarchical organization of 605 proteins in 109 assemblies that captures canonical repair mechanisms and proposes new DDR-associated proteins linked to stress, transport, and chromatin functions within cells.

via University of California San Diego|

#ddr #dna-damage #machine-learning