Mapping the Complex World of DNA Repair in Cells.
Scientists at the University of California San Diego School of Medicine have created a new map that shows the complex system of DNA damage response (DDR) in the human body. DDR is a network of cell-cycle checkpoints and DNA damage repair tools that help maintain the integrity of the genome and support normal functioning and health. The new map, which uses multi-omics and machine learning, shows a hierarchical organization of 605 proteins in 109 assemblies that captures canonical repair mechanisms and proposes new DDR-associated proteins linked to stress, transport, and chromatin functions within cells.