"MSL2: Ensuring Balanced Gene Expression in Mammals"
Originally Published 2 years ago — by Nature.com
A study has revealed that MSL2, a component of the MSL complex, plays a crucial role in ensuring biallelic gene expression in mammals. Using hybrid mouse cell line models, researchers found that MSL2 regulates the expression of haploinsufficient genes, which require both copies of the gene to produce a functional amount of protein. The loss of MSL2 resulted in allele-specific changes in gene expression, with some genes transitioning from biallelic to monoallelic expression. The chromatin landscape also underwent significant changes, with alterations in histone modifications and promoter-enhancer interactions. These findings shed light on the mechanisms underlying gene dosage regulation and provide insights into the role of MSL2 in maintaining balanced gene expression in mammals.