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All articles tagged with #lpa

Cholesterol guidelines urge earlier screening and expanded biomarker testing
health3 hours ago

Cholesterol guidelines urge earlier screening and expanded biomarker testing

New cholesterol guidelines urge starting screening in your 30s and using lifetime risk (via the PREVENT calculator) alongside 10-year risk to guide treatment. Targets are LDL <100 mg/dL for most, <70 mg/dL for high-risk individuals, and <55 mg/dL for those with existing heart disease, with statins considered earlier; the guidance also recommends apoB testing after LDL goals and universal lipoprotein(a) testing once in adulthood, plus calcium scoring for those at borderline/intermediate risk, all aiming to reduce lifetime LDL exposure and prevent cardiovascular events.

via NBC News|
#cholesterol#guidelines#health
Early Lipid-Lowering Urged: New Guidelines Target 30-Year-Olds
health4 hours ago

Early Lipid-Lowering Urged: New Guidelines Target 30-Year-Olds

New cardiovascular guidelines urge starting lipid management as early as age 30, using the PREVENT risk calculator and lower LDL targets (under 100 mg/dL for lower-risk, under 70 mg/dL for high risk, and under 55 mg/dL for very high risk). They endorse lifestyle changes, consider coronary calcium scans and biomarkers like Lp(a) and ApoB to guide therapy, and include statins and, in some cases, PCSK9 inhibitors as part of a broader prevention strategy.

via statnews.com|
#coronary-calcium-scan#health#ldl
Progress Nears in Developing Drug to Reduce Artery-Clogging Particle
health2 months ago

Progress Nears in Developing Drug to Reduce Artery-Clogging Particle

Researchers are nearing the completion of clinical trials for five experimental drugs aimed at lowering lipoprotein(a), a genetic particle linked to artery clogging and heart disease, with results expected in 2026. These drugs could significantly impact the treatment of a condition affecting about 20% of the global population, though cost and public awareness remain challenges.

via The Washington Post|
#cardiovascular-disease#clinical-trials#experimental-drugs
"Uncovering Silent Threats: The Hidden Dangers of Vascular Disease and Cholesterol"
health-medicine2 years ago

"Uncovering Silent Threats: The Hidden Dangers of Vascular Disease and Cholesterol"

Doctors warn that up to 65 million Americans may be at risk of deadly stroke or heart attack due to high levels of a specific type of cholesterol called lipoprotein(a), which is determined almost entirely by genetics and currently has no approved treatments. High levels of Lp(a) can lead to a two- to three-fold higher risk of heart attack and a nearly two-fold increased risk of stroke, often occurring at a relatively young age. Comprehensive cholesterol testing is being called for to detect high levels of Lp(a) and help patients mitigate their risks, while pharmaceutical companies are developing treatments to lower Lp(a) levels.

via Daily Mail|
#cardiovascular-disease#cholesterol#health-medicine
The Hidden Red Flag in Heart Attack Risk Assessment
health2 years ago

The Hidden Red Flag in Heart Attack Risk Assessment

Lipoprotein(a) or Lp(a) is a genetic risk factor that greatly increases the chances of a heart attack when present in high levels in the blood. Lp(a) causes atherosclerosis, inflammation, and increases the risk of clotting, making it a triple threat for heart disease. Approximately 20% of the population, particularly Black and South Asian Americans, are at risk due to Lp(a), yet fewer than 1% of Americans have had their levels checked. While there is currently no therapeutic available to directly reduce Lp(a), testing levels can help individuals mitigate overall cardiovascular risk by focusing on reducing other risk factors. Researchers are working on developing drugs to treat high Lp(a) levels, and clinical trials are underway.

via New York Post |
#cardiovascular-health#genetic-risk#health
"The Overlooked Red Flag in Assessing Heart Attack Risk, According to Doctors"
health2 years ago

"The Overlooked Red Flag in Assessing Heart Attack Risk, According to Doctors"

Lipoprotein(a) or Lp(a) is a protein that significantly increases the risk of heart attack when present in high levels in the blood. Lp(a) causes atherosclerosis, inflammation, and increases the risk of clotting, making it a triple threat for heart disease. Approximately 20% of the population, particularly Black and South Asian Americans, are at risk due to Lp(a), yet fewer than 1% of Americans have had their levels checked. While there is currently no therapeutic available to directly reduce Lp(a), it is important to reduce other cardiovascular risk factors. Testing Lp(a) levels can help individuals mitigate overall risk and make informed decisions about their health. Researchers are working on developing drugs to treat high Lp(a) levels, and lipoprotein apheresis is available for a small number of high-risk patients.

via Fox News|
#cardiovascular-health#genetic-risk-factor#health
"Groundbreaking Drug Slashes Heart Disease Risk by 96%"
health2 years ago

"Groundbreaking Drug Slashes Heart Disease Risk by 96%"

An experimental drug called lepodisiran has shown promising results in reducing blood levels of lipoprotein(a) (Lp(a)), a currently untreatable risk factor for heart disease. In a phase 1 trial, a single injection of lepodisiran lowered participants' high Lp(a) levels by as much as 96% from their baseline. Lepodisiran works by interfering with the genetic material that produces Lp(a), offering a potential solution for individuals with high Lp(a) levels who are unable to reduce this risk factor through lifestyle changes. Further trials are needed to confirm the drug's safety and effectiveness, but the initial results are encouraging.

via Freethink|
#experimental-drug#genetics#health