Cholesterol guidelines urge earlier screening and expanded biomarker testing

New cholesterol guidelines urge starting screening in your 30s and using lifetime risk (via the PREVENT calculator) alongside 10-year risk to guide treatment. Targets are LDL <100 mg/dL for most, <70 mg/dL for high-risk individuals, and <55 mg/dL for those with existing heart disease, with statins considered earlier; the guidance also recommends apoB testing after LDL goals and universal lipoprotein(a) testing once in adulthood, plus calcium scoring for those at borderline/intermediate risk, all aiming to reduce lifetime LDL exposure and prevent cardiovascular events.