Tag

Glycolysis

All articles tagged with #glycolysis

science9 days ago•8 min saved

Longevity Molecules May Fuel Cancer Growth Through a Hidden Pathway

New research from Tokyo University of Science shows polyamines—long linked to anti-aging effects via autophagy and mitochondria—can promote cancer by upregulating the translation factor eIF5A2 and boosting glycolysis, while altering ribosomal protein production. The study found polyamines lift suppression of eIF5A2 by miR-6514-5p, activating a cancer-promoting program distinct from eIF5A1’s aging-related role, suggesting context matters for polyamine supplements and identifying a potential target for cancer therapy.

via SciTechDaily|

#autophagy #cancer-metabolism #eif5a2

health2 years ago•3 min saved

Japanese Plum Juice Concentrate: A Heart-Healthy Remedy

Researchers at the Lewis Katz School of Medicine at Temple University have found that a simple juice concentrate from the Japanese plum, known as bainiku-ekisu, may reduce the risk of cardiovascular disease. The infused juice concentrate has been consumed in Japan as a health supplement since at least the 18th century. In experiments with mice, bainiku-ekisu was found to protect the vasculature from the effects of angiotensin II, a circulatory hormone that plays a central role in the development of hypertension. The juice concentrate also prevented the switch to glycolysis, suggesting that it protects against angiotensin II-induced hypertension by mitigating harmful metabolic changes that underlie hypertrophy and inflammation.

via Medical Xpress|

#bainiku-ekisu #cardiovascular-health #glycolysis

health2 years ago•6 min saved

Unlocking the Potential of Glucose Metabolism for Neurodegenerative Diseases.

Researchers at Gladstone Institutes and University of California, San Francisco have discovered that neurons are capable of taking up glucose and processing it into smaller metabolites, which could lead to a better understanding of neurodegenerative diseases like Alzheimer’s and Parkinson’s. The findings could contribute to the development of new therapeutic approaches and help understand how to maintain brain health as it ages. The study also showed that neurons rely on glycolysis for normal functioning and use other energy sources, such as galactose, when glucose is not available.

via SciTechDaily|

#brain-health #glucose-metabolism #glycolysis

neuroscience2 years ago•6 min saved

Insight into Neuronal Glucose Metabolism through "Sweet" Research

Neurons in the brain directly metabolize glucose through glycolysis to function normally, contrary to previous beliefs that glial cells metabolized the sugar and indirectly fuel neurons. The findings could provide insights into the development of new therapeutic approaches for neurodegenerative diseases like Alzheimer’s and Parkinson’s, where the brain’s uptake of glucose decreases in the early stages of the diseases. The study also showed that neurons rely on glycolysis for normal functioning and that they use other energy sources, such as galactose, when glucose is not available, but it is not as efficient.

via Neuroscience News|

#brain-health #glucose-metabolism #glycolysis