All articles tagged with #clinical applications
The article reviews emerging strategies, applications, and challenges of targeting NAD+ metabolism in clinical settings, highlighting its potential in treating age-related diseases, neurodegenerative disorders, and cancer, while discussing current research and therapeutic prospects.
Yale researchers have demonstrated that predictive models linking brain activity to behavior can generalize across diverse datasets, which is crucial for their clinical utility. By training models on varied brain imaging datasets, they found that these models can still perform accurately when tested on different datasets with unique demographic and regional characteristics. This highlights the importance of developing neuroimaging models that work for diverse populations, including underserved rural communities, to ensure equitable access to mental health care.
Scientists have developed a new method using bispecific single-domain antibodies, called BiCEs, to activate the complement system and target cancer cells more effectively. By linking a complement protein and a specific protein on the cancer cell surface, the BiCE molecules can activate the complement system, leading to the specific killing of cancer cells. This innovative approach has the potential to revolutionize cancer immunotherapy by engaging more of the body's immune response and could be translated into clinical applications.
The Human Brain Project (HBP) is taking brain simulation to the next level by modelling multiple scales at the same time, allowing researchers to study the brain in unprecedented ways. The HBP's multi-scale approach has yielded novel insights into brain function and opened the door for novel clinical applications, including advances in the treatment of epilepsy and Parkinson's disease. Personalized brain modelling has become a new approach for understanding and treating debilitating neurological diseases, and the HBP's EBRAINS research infrastructure is being interlinked to enable multi-scale simulation with connected platforms.