APOE Variants Could Drive the Majority of Alzheimer's Risk, Study Finds
A large analysis of about 470,000 people shows that the APOE gene, especially the ε3 and ε4 variants, accounts for most Alzheimer's risk, with ε3 not being neutral and ε2 offering protection. The findings imply APOE-focused therapies could prevent or reduce many cases, though translating this into treatments will be complex and lifestyle factors also influence risk; roughly half of dementia risk could be linked to APOE variations.