Maternal Genetics Linked to Embryo Chromosome Loss Risk

A Nature study analyzing 139,416 IVF embryos from 22,850 parental sets links maternal genetic variants to increased risk of embryonic chromosomal abnormalities (aneuploidy) that cause miscarriage; strongest ties involve meiotic genes such as SMC1B and others (C14orf39, CCNB1IP1, RNF212). While larger sample sizes clarify how inherited differences in meiosis influence risk, predicting individual outcomes remains difficult due to multiple factors beyond genetics. The work may inform reproductive genetics and drug development.