All articles tagged with #amr
Researchers discovered a new, potent antibiotic intermediate called pre-methylenomycin C lactone in the bacterium Streptomyces coelicolor, which is over 100 times more effective against resistant Gram-positive bacteria like MRSA and VRE, with no detected resistance development, offering promising potential in combating antimicrobial resistance.
Chemists from Warwick and Monash Universities discovered a new, potent antibiotic, pre-methylenomycin C lactone, hiding as an intermediate in the natural biosynthesis of methylenomycin A. This compound shows over 100 times greater activity against Gram-positive bacteria, including resistant strains like MRSA and VRE, and may offer a new approach to combat antimicrobial resistance. The next steps involve pre-clinical testing and further development.
The WHO reports a sharp global increase in antibiotic-resistant infections, especially in low and middle-income countries, with one in six bacterial infections showing resistance in 2023, raising concerns about limited treatment options and rising deaths from drug-resistant bacteria.
The WHO warns that antibiotic-resistant bacterial infections are surging globally, with one in six cases showing resistance in 2023, driven by overuse of antibiotics and inadequate surveillance, posing a serious threat to modern medicine and public health.
A 21-year-old woman from Northern Ireland developed a severe, antibiotic-resistant infection (MRSA) after a hip abscess, leading to long-term damage and the need for a hip replacement. Her case highlights the global threat of antimicrobial resistance (AMR), which makes infections harder to treat and endangers medical procedures, emphasizing the importance of responsible antibiotic use and the urgent need for new treatments.
Researchers warn of the rapid spread of antibiotic-resistant bacteria, particularly among vulnerable children in Niger, with potential to reach the UK, emphasizing the need for global investment in antimicrobial stewardship and hygiene infrastructure.
Models predict that if antimicrobial resistance (AMR) continues to rise without intervention, superbugs could cause millions of deaths and nearly $2 trillion in annual economic losses by 2050, with the US, UK, and EU among the hardest hit. The study highlights the importance of investing in new antibiotics and treatment programs, as current aid cuts may worsen the problem, leading to increased healthcare costs and workforce reductions worldwide.
A comprehensive study reveals that bacterial antimicrobial resistance (AMR) was linked to 569,000 deaths in the WHO Region of the Americas in 2019, representing 11.5% of global AMR-associated deaths. The leading causes were bacterial respiratory and bloodstream infections. Countries without a public National Action Plan (NAP) for AMR showed higher mortality rates. Urgent action is needed to address this health crisis, with experts comparing its threat to that of HIV/AIDS and malaria.