All articles tagged with #spliceosome
The study identifies de novo and inherited variants in U4 and U6 snRNA genes as causes of autosomal dominant retinitis pigmentosa, expanding the genetic landscape of the disease and highlighting the role of noncoding RNA mutations in retinal degeneration.
Researchers have identified a non-coding gene associated with intellectual disabilities, which encodes an RNA molecule part of the spliceosome complex. This discovery, based on whole genome sequencing data, highlights the importance of looking beyond protein-coding genes to understand genetic causes of neurodevelopmental disorders.
An international research team has discovered a previously unknown weak spot in prostate cancer cells involving a component of the minor spliceosome, which is significantly increased in advanced prostate cancer and drives uncontrolled cell growth. Inhibiting this component led to a significant reduction in prostate cancer growth compared to standard therapies, offering potential for more effective, targeted treatments. This discovery may also have implications for other types of cancer. The research was supported by the US Prostate Cancer Foundation with a $1 million grant.