All articles tagged with #serine
A study suggests that reducing dietary serine may make glioblastoma brain cancer more vulnerable to treatments by disrupting its metabolic processes, extending survival in mice when combined with chemoradiation, and paving the way for potential clinical trials in humans.
Scientists discovered that glioblastoma brain tumors in mice grow more slowly when deprived of the amino acid serine, revealing a potential metabolic vulnerability that could be targeted for therapy. The tumors typically steal nutrients like serine from their environment to support rapid growth, but a serine-deficient diet slowed tumor progression and extended survival in mice, offering new hope for treatment strategies.
Research suggests that depriving glioblastoma, an aggressive brain cancer, of the amino acid serine could slow tumor growth and potentially improve the effectiveness of chemotherapy by exploiting a metabolic vulnerability specific to the cancer.
A study published in Cell Metabolism warns that the amino acid serine, found in some brain supplements, may activate a gene linked to Alzheimer's disease. Researchers discovered elevated levels of the enzyme PGDH, which produces serine, in Alzheimer's patients, suggesting a potential risk in using serine supplements. The study highlights the need for caution and suggests that PGDH levels could serve as a marker for early dementia detection, offering a simpler method for diagnosing and monitoring Alzheimer's progression.