Tag

Protein Regulation

All articles tagged with #protein regulation

neuroscience1 year ago•3 min saved

"Regulating CaMKII for Alzheimer's Mitigation"

Researchers at the University of Colorado have identified three types of drug inhibitors that can regulate the CaMKII protein, which plays a crucial role in brain and heart function, to potentially mitigate Alzheimer's and heart conditions. These inhibitors offer a valuable tool for scientists to study the protein's functions and could lead to significant progress in treating brain diseases without harmful side effects. The research provides accessible tools for scientists across various disciplines to explore the protein's roles and functions.

via Neuroscience News|

#alzheimers #camkii #drug-inhibitors

health-and-science1 year ago•2 min saved

"Discovery of Immune System 'Switch' Prevents Attack on Healthy Cells"

Scientists have identified a "switch" that deactivates a sensor of foreign DNA, preventing the immune system from attacking healthy cells. This switch, a protein complex named CRL5–SPSB3, marks the enzyme cGAS for disposal when no immune response is required, providing insight into immune system regulation. Understanding this process could lead to potential therapeutic developments for autoimmune disorders, as it sheds light on how the immune system controls malfunction in conditions like type 1 diabetes and inflammatory bowel disease.

via ScienceAlert|

#autoimmune-disorders #cgas #health-and-science

health2 years ago•3 min saved

Promising Alzheimer's Treatment Restores Memory Function in Preclinical Study

A compound called 4-phenylbutyrate (PBA) has shown promise in reversing signs of Alzheimer's disease and improving memory function in a preclinical study using mice. PBA, known as a "chemical chaperone," inhibits protein accumulation and helps restore normal proteostasis in the brain. The treatment was effective even when administered late in the disease course and showed potential in reducing amyloid beta plaques, a hallmark of Alzheimer's. PBA is already approved by the FDA for another metabolic disorder and can easily cross the blood-brain barrier.

via Medical Xpress|

#alzheimers-disease #health #memory-function