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Neprilysin

All articles tagged with #neprilysin

health-and-medicine8 days ago•5 min saved

Brain receptors boost brain's natural cleaner to reduce Alzheimer's plaques

Researchers identified two brain receptors (SST1 and SST4) that regulate neprilysin, the enzyme that degrades amyloid beta. Activating both receptors in mice raised neprilysin levels, reduced amyloid buildup, and improved memory-related behavior, suggesting a potential for safe, affordable oral Alzheimer’s treatments that enhance the brain’s own plaque-cleaning system; however, findings are preclinical and require human studies.

via ScienceDaily|

#alzheimers-disease #amyloid-beta #drug-discovery

health1 month ago•3 min saved

Scientists Find Brain 'Switches' That Clear Alzheimer’s Plaques

Scientists have discovered two brain receptors, SST1 and SST4, that regulate the breakdown of amyloid beta, a protein linked to Alzheimer's disease. Activating these receptors increases neprilysin levels, reduces amyloid plaques, and improves memory in models, suggesting a potential new, safer, and less expensive treatment approach compared to current antibody therapies.

via SciTechDaily|

#alzheimers #amyloid-beta #brain-receptors

health2 years ago•4 min saved

Exercise-Induced Hormone Irisin: A Promising Defense Against Alzheimer's

The muscle hormone irisin, which is elevated during exercise, has shown potential in reducing amyloid beta deposits, a hallmark of Alzheimer's disease (AD). Researchers used 3D cell models of AD and found that irisin treatment led to a significant reduction in amyloid beta pathology by increasing levels of neprilysin, an enzyme responsible for breaking down amyloid beta. The study also identified the receptor, integrin αV/β5, on astrocytes that irisin binds to, triggering the release of neprilysin. These findings suggest that irisin-based therapies could be a potential treatment for AD in the future.

via Neuroscience News|

#alzheimers-disease #amyloid-beta #exercise