Exercise-Induced Hormone Irisin: A Promising Defense Against Alzheimer's

The muscle hormone irisin, which is elevated during exercise, has shown potential in reducing amyloid beta deposits, a hallmark of Alzheimer's disease (AD). Researchers used 3D cell models of AD and found that irisin treatment led to a significant reduction in amyloid beta pathology by increasing levels of neprilysin, an enzyme responsible for breaking down amyloid beta. The study also identified the receptor, integrin αV/β5, on astrocytes that irisin binds to, triggering the release of neprilysin. These findings suggest that irisin-based therapies could be a potential treatment for AD in the future.