Brain receptors boost brain's natural cleaner to reduce Alzheimer's plaques

Researchers identified two brain receptors (SST1 and SST4) that regulate neprilysin, the enzyme that degrades amyloid beta. Activating both receptors in mice raised neprilysin levels, reduced amyloid buildup, and improved memory-related behavior, suggesting a potential for safe, affordable oral Alzheimer’s treatments that enhance the brain’s own plaque-cleaning system; however, findings are preclinical and require human studies.