Tag

Molecularbiology

All articles tagged with #molecularbiology

science1 year ago•5 min saved

Real-Time Insights into DNA and mRNA Dynamics Unveiled

Scientists at EMBL Heidelberg have created the first real-time 'molecular movie' using single-molecule multi-colour fluorescence microscopy to observe interactions between RNA polymerase and ribosomes during transcription and translation in bacteria. This breakthrough provides insights into how these processes are coupled, potentially aiding in the development of new antibiotics by targeting these interactions. The study highlights the importance of basic research in understanding cellular mechanisms and combating antibiotic resistance.

via SciTechDaily|

#antibioticdevelopment #fluorescencemicroscopy #molecularbiology

science1 year ago•5 min saved

Revolutionizing Molecular Biology: Embracing a New Dogma

A new paradigm in molecular biology, termed the DNA/RNA Dogma, is emerging, challenging the traditional central dogma of DNA to RNA to protein to phenotype. This shift recognizes the significant role of RNA, particularly from non-protein-coding regions previously labeled as "junk DNA," in regulating protein expression and controlling genetic information flow. This new understanding aligns with Thomas Kuhn's concept of a paradigm shift, offering a more comprehensive view of genetic complexity and inheritance, akin to the shift from Newtonian physics to quantum theory.

via Forbes|

#dna #genomics #molecularbiology

science1 year ago•0 min saved

Scientists Engineer Mouse Using Microorganism Genes

Scientists have successfully created mouse stem cells using genes from a single-celled organism, marking a significant breakthrough in understanding the evolutionary leap from unicellular to multicellular life. These stem cells were used to develop a living mouse, demonstrating the potential of molecular tools in evolutionary biology, as reported in Nature Communications.

via The Washington Post|

#biotechnology #evolution #geneticengineering

science1 year ago•7 min saved

Decoding Memory: Molecular Signals in the Hippocampus

A study by ISTA and the Max Planck Institute reveals molecular mechanisms of memory formation in the hippocampus, focusing on mossy fiber synapses. Researchers found that proteins Cav2.1 and Munc13 rearrange during memory processing, enhancing synapse precision and power. Using live mouse brain tissue and advanced imaging, the study provides real-time insights into how neurotransmitters and synaptic plasticity enable the hippocampus to encode experiences, offering a foundation for understanding memory-related disorders.

via Neuroscience News|

#hippocampus #memory #molecularbiology

science-and-technology2 years ago•71 min saved

"Deciphering Bacterial 'Syringe' Loading: Shuttle Complexes and Pathogen Tactics"

Researchers have uncovered how the 'sorting platform' protein complexes in the bacterium Yersinia enterocolitica shuttle virulence effectors to the type III secretion system (T3SS), a mechanism critical for bacterial infection. Using in vivo proximity labeling and single-particle tracking super-resolution microscopy, they demonstrated that the sorting platform components SctQ and SctL directly interact with T3SS effectors in the cytosol, even in the absence of other essential T3SS membrane components. This interaction is dynamic and adjusts to external conditions, providing new insights into the initial steps of type III secretion and the path of T3SS effectors before their translocation into host cells. These findings could inform future research on targeted inhibition of bacterial secretion systems.

via Nature.com|

##bacterialpathogenesis #molecularbiology