Tag

Mitosis

All articles tagged with #mitosis

science-and-technology2 years ago•74 min saved

Unveiling the Cryo-EM Structures of PP2A:B55 Complexes with FAM122A and ARPP19

Cryo-EM structures of PP2A:B55–FAM122A and PP2A:B55–ARPP19 have been determined, shedding light on the molecular mechanisms of PP2A:B55 inhibition during mitotic entry. The structures reveal that ARPP19 and FAM122A bind to distinct regions of PP2A:B55, with ARPP19 binding in a tripartite manner involving three interaction sites. These findings provide valuable insights into the regulation of cell cycle progression and mitosis.

via Nature.com|

#arpp19 #b55 #fam122a

health2 years ago•4 min saved

Revealing the Surprising Truth Behind Cancer Drug Failures

A study from the University of Wisconsin–Madison reveals that common chemotherapy drugs, known as microtubule poisons, do not work by halting cell division as previously believed. Instead, these drugs alter mitosis, causing abnormal division that can lead to the death of cancer cells. The findings have significant implications for drug discovery efforts, as researchers have been focusing on developing therapies that mimic the supposed mechanism of microtubule poisons. The study suggests that efforts should be redirected towards disrupting mitosis and chromosomal segregation to improve cancer treatments.

via Medical Xpress|

#cancer-treatment #chemotherapy #drug-discovery

health2 years ago•2 min saved

Unraveling the Mystery of Cell Division Reversal

A study led by researchers at the National Cancer Institute (NCI) challenges the long-held belief that cells cannot reverse their decision to divide once they enter the cell cycle. The study found that cells preparing to divide can halt the division process and return to a resting state if interrupted early enough. This discovery could lead to more effective treatments for interrupting the rapid division and spread of cancer cells. The researchers suggest that drugs inhibiting cell cycle regulators CDK4 and CDK6, such as the breast cancer drug palbociclib, may work differently than previously thought and could be combined with traditional chemotherapy drugs to design more durable therapies.

via National Institutes of Health (.gov)|

#cancer-research #cdk46-inhibitors #cell-cycle

genetics2 years ago•26 min saved

Mitotic tethering and chromatin reprogramming for cellular inheritance and regeneration.

Mitotic tethering, a process where DNA ends are held together during cell division, enables the inheritance of shattered micronuclear chromosomes, a common cause of genomic rearrangements in cancer. Researchers found that the CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis by tethering DNA ends, preventing chromosome pulverization and promoting proper chromosome segregation. The study sheds light on the mechanisms behind chromothripsis and may lead to new therapeutic targets for cancer treatment.

via Nature.com|

#chromosome-segregation #chromothripsis #dna-damage