Mitotic tethering and chromatin reprogramming for cellular inheritance and regeneration.
Mitotic tethering, a process where DNA ends are held together during cell division, enables the inheritance of shattered micronuclear chromosomes, a common cause of genomic rearrangements in cancer. Researchers found that the CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis by tethering DNA ends, preventing chromosome pulverization and promoting proper chromosome segregation. The study sheds light on the mechanisms behind chromothripsis and may lead to new therapeutic targets for cancer treatment.