All articles tagged with #melanocyte stem cells
A study reveals that melanocyte stem cells respond to DNA damage by either undergoing senescence-coupled differentiation, leading to hair graying and protecting against cancer, or bypassing this process under carcinogenic stress, which may increase melanoma risk, highlighting a link between tissue aging and cancer prevention mechanisms.
Emerging research suggests that grey hair may be an outward sign of the body's protective response against cancer, with damaged melanocyte stem cells either undergoing differentiation and disappearing (causing grey hair) or bypassing this process and potentially leading to melanoma, highlighting a complex link between aging, cellular damage, and cancer risk.
A groundbreaking study suggests that gray hair may be reversibly colored by restoring the proper movement and timing of pigment stem cells within hair follicles, potentially leading to treatments that can reverse or prevent graying by fixing cellular traffic issues, based on research in mice and applicable to humans.
A new study published in the journal Nature and led by researchers from New York University’s Grossman School of Medicine has found that gray hair may be reversible. The study links graying hair to melanocyte stem cells (McSCs) getting stuck, unable to color new hair growth. Restoring mobility of the cells could allow the continuation of pigment production, eliminating graying hair. The next step for the NYU team involves looking at how to get McSCs, once stuck, moving again.
Melanocyte stem cells (McSCs) are responsible for hair pigmentation, but with age, they can get stuck and become unable to perform their function, leading to hair graying. Researchers found that McSCs can switch between stem cell and maturing states, and dedifferentiate back into stem cells. The loss of chameleon-like function in McSCs may be responsible for graying and loss of hair color. The findings suggest that if McSC movement could be restored, it might prevent or reverse hair graying.
New research has found that gray hair may be preventable or even reversible by moving melanocyte stem cells to their proper location, where they continue to mature and generate pigment. This study also shows promise in the area of cancer research, as melanocytes are the cell types that proliferate uncontrollably in melanoma. While this new revelation is exciting, the research still has a way to go before it can be used safely in humans. Genetics and environmental factors such as UV radiation and pollution also play a role in premature graying.
Researchers at NYU Grossman School of Medicine have found that certain stem cells called melanocyte stem cells (McSCs) have the ability to maintain the original pigment in hair strands. As hair ages, more McSCs become stuck in a compartment called the hair follicle bulge, where they fail to mature into pigment-producing cells. The scientists hope this research may lead to answers for keeping hair healthy and colored long into old age. The team plans to investigate means of restoring the motility of McSCs or physically moving them back to their germ compartment where they can produce pigment, thus stopping hairs from turning gray.
Scientists have discovered that melanocyte stem cells become stuck inside the hair follicle and are unable to produce pigment, causing hair to turn grey as we age. The pigment-producing part of a stem cell changes as the hair ages, sheds, and grows back. The stem cells get stuck in a part of the hair follicle called the hair follicle bulge, failing to mature into fully-fledged melanocytes. The researchers suggest that their findings could open up a potential way to reverse or prevent grey hair by helping jammed cells to move again between developing hair follicle compartments.
Researchers at NYU have discovered that melanocyte stem cells (McSCs) control hair color and that with age, these cells slow down and get trapped in the hair follicle bulge, leading to gray hair. The study, conducted on mice, found that getting the McSCs moving again could prevent or reverse graying in humans. The researchers are now focused on investigating ways to restore the motility of McSCs or physically move them back to their germ compartment to produce pigment.
Melanocyte stem cells (McSCs) lose their ability to move between hair follicle compartments as people age, leading to hair graying. McSCs are plastic, meaning they continually shift between maturity stages and compartments within hair follicles. However, as hair ages and regrows repeatedly, more McSCs become stuck in the hair follicle bulge and are unable to mature into pigment-producing cells. Restoring McSC motility or moving them back to their germ compartment could potentially reverse or prevent hair graying in humans.
Researchers have discovered that certain stem cells, called melanocyte stem cells, get stuck in hair follicles as people age, causing hair to turn gray. The study, which focused on cells in the skin of mice, suggests that the same fixed-positioning of melanocyte stem cells may exist in humans, presenting a potential pathway for reversing or preventing the graying of human hair by helping jammed cells to move again between developing hair follicle compartments.
Scientists have discovered that stem cells may get stuck as hair ages, resulting in greying hair. The study focused on melanocyte stem cells in mice and found that as hair ages, increasing numbers of these cells get stuck in the stem cell compartment of the hair follicle bulge, where they remain. The researchers suggest that if their findings hold true for humans, it could open up a potential way to reverse or prevent grey hair by helping jammed cells to move again between developing hair follicle compartments.
Melanocyte stem cells (McSCs) get stuck in the stem cell compartment of hair follicles as people age, losing their ability to mature and maintain hair color, according to a study by researchers from NYU Grossman School of Medicine. The study found that McSCs transform between their most primitive stem cell state and the next stage of their maturation, the transit-amplifying state, and depending on their location. The researchers plan to investigate means of restoring the motility of McSCs or of physically moving them back to their germ compartment, where they can produce pigment.
Stem cells required for hair pigmentation, called melanocyte stem cells (McSCs), can become "stuck" in a particular compartment of the hair follicle, preventing their differentiation and the maintenance of hair color, according to a new study by NYU Langone researchers. The researchers used 3D imaging and single-cell RNA sequencing to track McSC cells in mice as they aged and moved within hair follicles during a two-year study. The study suggests that the loss of chameleon-like function in McSCs may be responsible for graying and loss of hair color, and there could be opportunities to intervene with hair graying by helping the "jammed" cells to move between the hair follicle compartments once again.
While there may not be a direct link between stress and gray hair, recent studies suggest that stress, along with genetics and ethnicity, may contribute to the development of gray hair. Chronic stress can lead to various health and cognitive issues, and it's a cycle that's tough to break. Relaxation techniques, exercise, and social engagement can help reduce stress. Additionally, a recent study found that gray hair may revert back to its original color while on vacation, suggesting a link between stress and gray hair that may be reversible.