Gene discovery brings male contraception closer to reality.

Researchers at Washington State University have identified a gene, Arrdc5, that is expressed only in testicular tissue and is found in multiple mammalian species, including humans. Knocking out the gene in male mice created infertility by impacting their sperm count, movement, and shape. The protein encoded by this gene is required for normal sperm production, and the team will work on designing a drug that would inhibit its production or function, making it easily reversible as a contraceptive. The discovery could pave the way for a highly effective, reversible, and non-hormonal male contraceptive for humans and animals.