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Lung Diseases

All articles tagged with #lung diseases

medical-technology2 years ago

Radiologists trump AI in detecting lung diseases on chest X-rays

Radiologists outperformed commercially available AI tools in accurately identifying the presence and absence of three common lung diseases on chest X-rays, according to a study published in Radiology. While AI tools showed moderate to high sensitivity rates, they produced more false-positive results than radiologists, especially when multiple findings were present or for smaller targets. The study highlights the need for further testing of AI tools in real-life clinical scenarios and emphasizes the importance of radiologists' expertise in interpreting complex chest X-rays. AI systems could serve as a valuable second opinion for radiologists but should not be autonomous in making diagnoses.

via EurekAlert|
#ai#chest-x-rays#diagnostic-accuracy
health2 years ago

"Revolutionary Stem Cells Show Promise in Regenerating PF-Damaged Tissue"

Scientists have developed a method to use engineered specialized stem cells to regenerate healthy airway tissues, offering a potential treatment for chronic lung diseases like pulmonary fibrosis (PF). In preclinical studies, researchers engineered lung stem cells and successfully repopulated lungs with healthy cells in mouse models of lung injury. The use of induced pluripotent stem cells (iPSCs) allows for the creation of specialized lung stem cells in the lab, which can be derived from a patient's own cells, potentially avoiding the need for immunosuppression. While the road to clinical development for lung diseases may be long, this research marks a significant step forward in the potential use of iPSC-based lung regeneration as a treatment approach.

via Pulmonary Fibrosis News|
#health#lung-diseases#pulmonary-fibrosis
health2 years ago

Revolutionary mRNA Nanoparticles Combat Lung Diseases.

MIT and University of Massachusetts Medical School engineers have developed nanoparticles that can deliver messenger RNA encoding useful proteins to the lungs, with potential applications in treating cystic fibrosis and other lung diseases. The particles facilitated efficient delivery of mRNA encoding CRISPR/Cas9 gene-editing components, paving the way for therapeutic nanoparticles capable of replacing disease-causing genes. The researchers are working on aerosolizing the nanoparticles for inhalation and plan to test the particles in a mouse model of cystic fibrosis and other lung diseases.

via SciTechDaily|
#crisprcas9#gene-editing#health
science-and-technology2 years ago

"Revolutionary Lung Gene Editing Techniques Utilizing Novel Nanoparticles and Lipids"

Researchers have developed a new method for delivering CRISPR RNA to the lungs using improved lipid nanoparticles. By synthesizing and screening 720 novel lipids, the authors identified a nanoparticle formulation that achieves moderately efficient editing in the mouse lung after intratracheal delivery of CRISPR RNA-LNPs. This achievement paves the way for therapeutic CRISPR applications in the lung that involve not only gene editing but also gene therapy. The approach should aid the discovery of gene-editing drugs that are effective in treating lung diseases in animal models and, with further optimization, could provide an enabling technology for clinical applications.

via Nature.com|
#crispr#gene-editing#lipid-nanoparticles
health2 years ago

Nanoparticles enable gene editing and protein delivery in lungs.

Researchers at MIT and the University of Massachusetts Medical School have developed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins. The particles could offer an inhalable treatment for cystic fibrosis and other diseases of the lung. The researchers used the particles to deliver mRNA encoding the machinery needed for CRISPR/Cas9 gene editing, which could open the door to designing therapeutic nanoparticles that can snip out and replace disease-causing genes. The new particles also break down quickly, allowing them to be cleared from the lung within a few days and reducing the risk of inflammation.

via MIT News|
#crisprcas9#gene-editing#health