Tag

Drug Target

All articles tagged with #drug target

science1 year ago•4 min saved

"Proposing a Paradigm Shift in Enzyme Biochemistry: A Researcher's Perspective"

Researchers at Vanderbilt University propose a paradigm shift in enzyme biochemistry by uncovering the mechanism used by cytochrome P450 51 to catalyze the critical final step in sterol biosynthesis. Their study, published in Angewandte Chemie, suggests that both Compound 0 and Compound I play active roles in the process, with Compound 0 being the major heme species responsible for the reaction. The findings provide a deeper understanding of P450 51 function in humans and various pathogens, offering potential insights for the development of P450 51-targeted drugs, particularly in the context of antifungal resistance and the need for novel treatments.

via Phys.org|

#cytochrome-p450 #drug-target #enzyme-biochemistry

health2 years ago•4 min saved

"Breakthrough Study Identifies Promising Drug Target for Alzheimer's Based on Largest Genetic Risk Factor"

Scientists at Gladstone Institutes have discovered that neurons producing the APOE4 gene variant release an immune signaling molecule called HMGB1 at higher rates, which activates brain immune cells called microglia, leading to inflammation and neurodegeneration. By blocking the release of HMGB1 with experimental drugs, mouse models showed reduced microglial activation and neurodegeneration. This finding suggests that targeting HMGB1 could be a potential drug target for treating APOE4-related Alzheimer's disease.

via Medical Xpress|

#alzheimers-disease #apoe4-gene #drug-target

science2 years ago•3 min saved

Unveiling the Regulation of Rhomboid Protease Activity

Researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have discovered a mechanism for regulating the activity of rhomboid proteases, which are promising drug targets. The researchers found that the dynamics of the gate in these proteases play a key role in enzyme activity. By using a combination of experimental and theoretical techniques, including solid-state NMR spectroscopy and molecular dynamics simulations, they demonstrated a correlation between gate dynamics and enzyme activity. The findings provide valuable insights for understanding the functioning of rhomboid proteases and may contribute to the development of new compounds for therapeutic purposes.

via Phys.org|

#biophysical-methods #drug-target #enzyme-activity

health2 years ago•3 min saved

Scientists Identify Anxiety Gene and Natural Off Switch in the Brain

Scientists have discovered a brain gene, Pgap2, linked to anxiety symptoms, and found that a molecule, miR483-5p, suppresses it, suggesting a potential mechanism for anxiety relief and a new drug target. Anxiety disorders are common, but currently available anti-anxiety drugs have limited efficacy. The study identified the molecular events in the brain that underpin anxiety and found that miR-483-5p acts as a molecular brake that offsets stress-induced amygdala changes to promote anxiety relief. The discovery of a novel amygdala miR483-5p/Pgap2 pathway through which the brain regulates its response to stress is the first stepping stone towards the discovery of novel, more potent, and much-needed treatments for anxiety disorders that will enhance this pathway.

via SciTechDaily|

#anxiety #brain-gene #drug-target

neuroscience2 years ago•4 min saved

Scientists Identify Gene in the Brain that Controls Anxiety

Scientists have identified a gene in the brain responsible for anxiety symptoms and found that modifying the gene can reduce anxiety levels, offering a novel drug target for anxiety disorders. The discovery highlights a new amygdala miR483-5p/Pgap2 pathway that regulates the brain’s response to stress and provides a potential therapeutic approach for anxiety disorders. Anxiety disorders are common with one in four people diagnosed with a disorder at least once in their lifetime.

via Neuroscience News|

#amygdala #anxiety #drug-target