Unveiling the Regulation of Rhomboid Protease Activity
Researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have discovered a mechanism for regulating the activity of rhomboid proteases, which are promising drug targets. The researchers found that the dynamics of the gate in these proteases play a key role in enzyme activity. By using a combination of experimental and theoretical techniques, including solid-state NMR spectroscopy and molecular dynamics simulations, they demonstrated a correlation between gate dynamics and enzyme activity. The findings provide valuable insights for understanding the functioning of rhomboid proteases and may contribute to the development of new compounds for therapeutic purposes.