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Cd4 T Cells

All articles tagged with #cd4 t cells

health-and-medicine28 days ago•6 min saved

CD27 boost could unlock long-lasting cancer vaccine immunity

A 20-year-old breast cancer vaccine trial shows all participants are still alive decades later, suggesting durable immune memory. Researchers found persistent CD27-marked CD4+ T cells can recognize the cancer, hinting that CD27 could make cancer vaccines more effective. In mice, combining the vaccine with a CD27-activating antibody nearly doubled tumor elimination (about 40% complete responses vs 6% with vaccine alone); adding extra support for CD8+ T cells pushed tumor rejection to ~90%. These findings imply CD27 could be a key addition to cancer vaccines and compatible with existing therapies.

via ScienceDaily|

#cancer-vaccine #cd27 #cd4-t-cells

science1 month ago•7 min saved

Decades-Old Breast Cancer Vaccine Triggers Durable Immune Memory, New Boosting Approach Emerges

Researchers studied survivors from a decades-old breast cancer vaccine trial and found they retain powerful CD27+ immune memory years later. In mice, combining a CD27-activating antibody with a HER2-targeting vaccine dramatically increased tumor rejection, largely via CD4+ T cells and, with additional CD8+ T-cell support, boosted efficacy to near 90%. The findings suggest CD4+ T cells can drive lasting anti-tumor immunity and that a single CD27 boost alongside vaccines could enhance cancer immunotherapies in humans.

via SciTechDaily|

#cancer-vaccine #cd27 #cd4-t-cells

medical-research2 years ago•4 min saved

Revolutionary Immunotherapy Treatment for Glioblastoma Unveiled by Salk Scientists

Scientists at the Salk Institute have discovered that the immunotherapy treatment anti-CTLA-4 leads to significantly greater survival rates in mice with glioblastoma, the most common and deadly form of brain cancer. The treatment relies on CD4+ T cells infiltrating the brain and triggering the tumor-destructive activities of microglia, immune cells that reside in the brain. This finding highlights the potential of harnessing the body's own immune cells to fight brain cancer and could lead to more effective immunotherapies for treating glioblastoma in humans.

via News-Medical.Net|

#brain-cancer #cd4-t-cells #glioblastoma

neurology2 years ago•3 min saved

"Insights into Long COVID: Immune Dysregulation, Genetic Impact, and CBT Benefits"

A small cohort study conducted by the National Institute of Neurological Disorders and Stroke (NINDS) of the NIH in Bethesda, Maryland, found that people with long COVID neurologic symptoms had broad immune dysregulation in their cerebrospinal fluid (CSF), with lower levels of CD4+ and CD8+ T cells and increased B cells and other types of immune cells. Autonomic testing also showed dysfunction. The findings suggest that immune dysregulation may play a role in mediating long COVID and call for further investigations to confirm these changes and evaluate the role of immunomodulatory agents in clinical trials.

via Medpage Today|

#autonomic-dysfunction #cd4-t-cells #cd8-t-cells