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Creatine Shows Promise in Alzheimer's Treatment and Brain Health
7 months ago•Source: MedPage Today
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2.725 min•2 years ago
The Alarming Surge of Prion Diseases in the U.S.
The incidence of Creutzfeldt-Jakob disease (CJD), a fatal prion disease, has been steadily increasing in the United States, particularly among women. From 2007 to 2020, the incidence of CJD rose from 1.06 to 1.58 per million in women and from 1.05 to 1.47 per million in men. The increase remained significant for women even after adjusting for age. The rise in incidence may be due to changing demographics or improved detection with new diagnostic tools. The study highlights the need for monitoring among the aging U.S. population.
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Unraveling the Impact of Long COVID on the Brain
Medpage Today•2 years ago
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Physician Group's New Statement on Determining Death
Medpage Today•2 years ago
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Limited Eligibility for Lecanemab in Early Alzheimer's Patients
Only a small percentage of individuals with early Alzheimer's disease meet the eligibility criteria for the anti-amyloid monoclonal antibody treatments lecanemab and aducanumab, according to data from the Mayo Clinic Study of Aging. The study found that out of 237 participants with mild cognitive impairment or mild dementia and increased brain amyloid, only 8% qualified for a lecanemab trial and 5.1% qualified for an aducanumab trial. The researchers noted that the strict criteria, which include chronic health conditions and brain scan abnormalities, limit the number of eligible candidates. Further research is needed to assess the safety and efficacy of these treatments in larger and more diverse populations before they can be widely available to Alzheimer's patients.
"Insights into Long COVID: Immune Dysregulation, Genetic Impact, and CBT Benefits"
A small cohort study conducted by the National Institute of Neurological Disorders and Stroke (NINDS) of the NIH in Bethesda, Maryland, found that people with long COVID neurologic symptoms had broad immune dysregulation in their cerebrospinal fluid (CSF), with lower levels of CD4+ and CD8+ T cells and increased B cells and other types of immune cells. Autonomic testing also showed dysfunction. The findings suggest that immune dysregulation may play a role in mediating long COVID and call for further investigations to confirm these changes and evaluate the role of immunomodulatory agents in clinical trials.
COVID-19 Linked to Neurological Disorders and Increased MS Disability.
Patients with functional neurological disorder (FND) after COVID-19 infection had different symptoms than people with FND after COVID-19 vaccines, according to a retrospective study. Those with FND after COVID-19 vaccination more closely resembled classic FND, while those with post-COVID FND tended to be older, had more insidious onset, and had higher disability. The findings point to a need to consider FND when diagnosing patients with post-COVID neurologic symptoms.