Tag

Cartilage

All articles tagged with #cartilage

health2 years ago•2 min saved

"Promising Discoveries and Trials Offer Hope for Reversing Osteoarthritis"

Researchers at the University of Adelaide have discovered that osteoarthritis (OA) in mice is caused by the depletion of specialized gene-expressing cartilage-forming stem cells and have found a way to reverse the condition. The study suggests that OA may be treatable and reversible, challenging the notion that it is a "wear and tear" condition. By targeting fibroblast growth factor signaling, the researchers were able to stimulate the proliferation of these stem cells and achieve significant recovery of cartilage thickness and reduced OA. While the findings need to be tested in human subjects, a clinical trial using a similar approach has shown promise in improving cartilage thickness and volume.

via New Atlas|

#cartilage #health #osteoarthritis

health2 years ago•2 min saved

Revolutionary Treatment Approach Unveiled for Osteoarthritis and Neurodegenerative Diseases

Researchers have discovered that elevated levels of the protein c-Fos are associated with the severity of osteoarthritis, a common degenerative joint disease affecting over 500 million people worldwide. This breakthrough provides new insights into potential targeted therapies and challenges the previous belief that osteoarthritis solely stems from wear and tear. The study, led by scientists at MedUni Vienna, found that c-Fos is secreted by cartilage cells in response to osteoarthritis signals and plays a role in protecting cartilage. The research team also deciphered the mechanism controlling the production and accumulation of c-Fos in cartilage cells, paving the way for the development of targeted therapies.

via SciTechDaily|

#cartilage #health #joint-disease

health2 years ago•4 min saved

"Breakthrough Discovery: Protein Shields Joints from Osteoarthritis"

Researchers have identified a previously unstudied protein called adseverin that plays a critical role in protecting healthy joints from osteoarthritis. Adseverin helps maintain the structural scaffolding of cells, known as F-actin, which acts as a shield against the stresses on cartilage cells. Loss of F-actin leads to cell death and the degradation of cartilage. The findings may open doors to developing therapeutics targeting adseverin or F-actin to prevent joint degradation and improve osteoarthritis treatments.

via Medical Xpress|

#cartilage #health #joint-health

health2 years ago•3 min saved

Young cartilage eases arthritis pain.

Researchers are using cartilage from healthy joints that have been discarded due to polydactyly, a condition where a person is born with extra digits, to replace worn-out cartilage in patients with osteoarthritis of the knee. All ten patients treated with small sheets of cartilage made from unwanted fingers and toes as part of a pilot project at Tokai University in Tokyo, Japan, went on to show complete regeneration of their own cartilage in damaged knees over the following 12 months, avoiding the need for a replacement knee joint. This technique has the potential to allow people to walk their entire lives on their own knees, without requiring artificial joints.

via Daily Mail|

#arthritis #cartilage #health