Enzyme Inhibition Reverses Cartilage Degeneration Without Stem Cells
TL;DR Summary
Scientists have shown in mice that inhibiting the aging enzyme 15-PGDH can regrow cartilage without stem cells, with treated cartilage thickening into hyaline cartilage and reprogramming existing joint cells to build tissue. Early tests on human cartilage also show reduced enzyme activity and initial matrix rebuilding, suggesting a potential, less invasive path to treating osteoarthritis, though research is in early stages.
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