Genetic Variants Linked to Dementia Resilience in Superagers, Study Finds
In a study of 18,080 participants (1,623 superagers aged 80+, 8,829 with Alzheimer's, 7,628 controls), researchers found that superagers are less likely to carry the APOE-e4 Alzheimer's-risk variant and more likely to carry APOE-e2, suggesting genetics contribute to exceptional aging and reduced dementia risk. The pattern held in non-Hispanic White groups, highlighting a potential genetic basis for dementia resilience, though lifestyle and other factors remain important, and more diverse research is needed.