Aging Memory Decline Tied to Widespread Brain Changes Across Regions
TL;DR Summary
A large multicohort study of 3,737 cognitively healthy participants with 10,343 MRI scans and 13,460 memory assessments finds episodic memory declines with age are linked to broad brain tissue loss rather than a single region, with stronger effects after age 60 and more pronounced in APOE ε4 carriers; results imply aging-related cognitive decline shares mechanisms with neurodegenerative diseases and may require early, multi-area interventions across the brain.
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